Tissue-Specific Decellularization Methods: Rationale and Strategies to Achieve Regenerative Compounds

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ijms-21-05447-v2.pdf (1.69 MB)
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URI: http://hdl.handle.net/11556/974
ISSN: 1661-6596
ESSN: 1422-0067
DOI: 10.3390/ijms21155447
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2020-07-30
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Multidisciplinary Digital Publishing Institute (MDPI)
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Abstract
The extracellular matrix (ECM) is a complex network with multiple functions, including specific functions during tissue regeneration. Precisely, the properties of the ECM have been thoroughly used in tissue engineering and regenerative medicine research, aiming to restore the function of damaged or dysfunctional tissues. Tissue decellularization is gaining momentum as a technique to obtain potentially implantable decellularized extracellular matrix (dECM) with well-preserved key components. Interestingly, the tissue-specific dECM is becoming a feasible option to carry out regenerative medicine research, with multiple advantages compared to other approaches. This review provides an overview of the most common methods used to obtain the dECM and summarizes the strategies adopted to decellularize specific tissues, aiming to provide a helpful guide for future research development.
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Extracellular matrix , Decellularization , Regenerative medicine
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journal article
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Mendibil, Unai, Raquel Ruiz-Hernandez, Sugoi Retegi-Carrion, Nerea Garcia-Urquia, Beatriz Olalde-Graells, and Ander Abarrategi. “Tissue-Specific Decellularization Methods: Rationale and Strategies to Achieve Regenerative Compounds.” International Journal of Molecular Sciences 21, no. 15 (July 30, 2020): 5447. doi:10.3390/ijms21155447