Tissue-Specific Decellularization Methods: Rationale and Strategies to Achieve Regenerative Compounds

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dc.contributor.authorMendibil, Unai
dc.contributor.authorRuiz-Hernandez, Raquel
dc.contributor.authorRetegi-Carrion, Sugoi
dc.contributor.authorGarcia-Urquia, Nerea
dc.contributor.authorOlalde-Graells, Beatriz
dc.contributor.authorAbarrategi, Ander
dc.date.accessioned2020-09-09T11:21:42Z
dc.date.available2020-09-09T11:21:42Z
dc.date.issued2020-07-30
dc.description.abstractThe extracellular matrix (ECM) is a complex network with multiple functions, including specific functions during tissue regeneration. Precisely, the properties of the ECM have been thoroughly used in tissue engineering and regenerative medicine research, aiming to restore the function of damaged or dysfunctional tissues. Tissue decellularization is gaining momentum as a technique to obtain potentially implantable decellularized extracellular matrix (dECM) with well-preserved key components. Interestingly, the tissue-specific dECM is becoming a feasible option to carry out regenerative medicine research, with multiple advantages compared to other approaches. This review provides an overview of the most common methods used to obtain the dECM and summarizes the strategies adopted to decellularize specific tissues, aiming to provide a helpful guide for future research development.en
dc.description.sponsorshipThis work was supported by the Spanish “Programa Estatal de I+D+i Orientada a los Retos de la Sociedad”, grant number RTI2018-101708-A-I00. S.R.-C. was supported by Fomento de San Sebastian innovative talent programme, grant number 0508/2019/0009. R.R.-H. was supported by Spanish State Training Subprogramme, grant number PRE2018-084542. A.A. was supported by Spanish State Subprogramme of Incorporation Ramón y Cajal, grant number RYC2018-025502-I, and 2019 Leonardo Grant for Researchers and Cultural Creators, BBVA Foundation, grant number IN[19]_CMA_BIO_0119.en
dc.divisionSaluden
dc.identifier.citationMendibil, Unai, Raquel Ruiz-Hernandez, Sugoi Retegi-Carrion, Nerea Garcia-Urquia, Beatriz Olalde-Graells, and Ander Abarrategi. “Tissue-Specific Decellularization Methods: Rationale and Strategies to Achieve Regenerative Compounds.” International Journal of Molecular Sciences 21, no. 15 (July 30, 2020): 5447. doi:10.3390/ijms21155447en
dc.identifier.doi10.3390/ijms21155447en
dc.identifier.essn1422-0067en
dc.identifier.issn1661-6596en
dc.identifier.urihttp://hdl.handle.net/11556/974
dc.issue.number15en
dc.journal.titleInternational Journal of Molecular Sciencesen
dc.language.isoengen
dc.page.initial5447en
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)en
dc.rightsAttribution 4.0 International*
dc.rights.accessRightsopen accessen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.keywordsExtracellular matrixen
dc.subject.keywordsDecellularizationen
dc.subject.keywordsRegenerative medicineen
dc.titleTissue-Specific Decellularization Methods: Rationale and Strategies to Achieve Regenerative Compoundsen
dc.typejournal articleen
dc.volume.number21en
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