RT Journal Article
T1 Tissue-Specific Decellularization Methods: Rationale and Strategies to Achieve Regenerative Compounds
A1 Mendibil, Unai
A1 Ruiz-Hernandez, Raquel
A1 Retegi-Carrion, Sugoi
A1 Garcia-Urquia, Nerea
A1 Olalde-Graells, Beatriz
A1 Abarrategi, Ander
AB The extracellular matrix (ECM) is a complex network with multiple functions, includingspecific functions during tissue regeneration. Precisely, the properties of the ECM have beenthoroughly used in tissue engineering and regenerative medicine research, aiming to restore thefunction of damaged or dysfunctional tissues. Tissue decellularization is gaining momentum asa technique to obtain potentially implantable decellularized extracellular matrix (dECM) withwell-preserved key components. Interestingly, the tissue-specific dECM is becoming a feasible optionto carry out regenerative medicine research, with multiple advantages compared to other approaches.This review provides an overview of the most common methods used to obtain the dECM andsummarizes the strategies adopted to decellularize specific tissues, aiming to provide a helpful guidefor future research development.
PB Multidisciplinary Digital Publishing Institute (MDPI)
SN 1661-6596
YR 2020
FD 2020-07-30
LK http://hdl.handle.net/11556/974
UL http://hdl.handle.net/11556/974
LA eng
NO Mendibil, Unai, Raquel Ruiz-Hernandez, Sugoi Retegi-Carrion, Nerea Garcia-Urquia, Beatriz Olalde-Graells, and Ander Abarrategi. “Tissue-Specific Decellularization Methods: Rationale and Strategies to Achieve Regenerative Compounds.” International Journal of Molecular Sciences 21, no. 15 (July 30, 2020): 5447. doi:10.3390/ijms21155447
NO This work was supported by the Spanish “Programa Estatal de I+D+i Orientada a los Retos de la Sociedad”, grant number RTI2018-101708-A-I00. S.R.-C. was supported by Fomento de San Sebastian innovative talent programme, grant number 0508/2019/0009. R.R.-H. was supported by Spanish State Training Subprogramme, grant number PRE2018-084542. A.A. was supported by Spanish State Subprogramme of Incorporation Ramón y Cajal, grant number RYC2018-025502-I, and 2019 Leonardo Grant for Researchers and Cultural Creators, BBVA Foundation, grant number IN[19]_CMA_BIO_0119.
DS TECNALIA Publications
RD 1 jul 2024