%0 Journal Article
%A Mendibil, Unai
%A Ruiz-Hernandez, Raquel
%A Retegi-Carrion, Sugoi
%A Garcia-Urquia, Nerea
%A Olalde-Graells, Beatriz
%A Abarrategi, Ander
%T Tissue-Specific Decellularization Methods: Rationale and Strategies to Achieve Regenerative Compounds
%D 2020
%@ 1661-6596
%U http://hdl.handle.net/11556/974
%X The extracellular matrix (ECM) is a complex network with multiple functions, includingspecific functions during tissue regeneration. Precisely, the properties of the ECM have beenthoroughly used in tissue engineering and regenerative medicine research, aiming to restore thefunction of damaged or dysfunctional tissues. Tissue decellularization is gaining momentum asa technique to obtain potentially implantable decellularized extracellular matrix (dECM) withwell-preserved key components. Interestingly, the tissue-specific dECM is becoming a feasible optionto carry out regenerative medicine research, with multiple advantages compared to other approaches.This review provides an overview of the most common methods used to obtain the dECM andsummarizes the strategies adopted to decellularize specific tissues, aiming to provide a helpful guidefor future research development.
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