Near-optimum heating profiles in freeze-drying in accordance to the transport parameters and product nature

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URI: https://hdl.handle.net/11556/1935
ISBN: 0444893520
ISBN: 9780444893529
Publication date
1991
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Amsterdam, The Netherlands, Elsevier Science Publishers
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Abstract
A simplified mathematical sublimation model is presented to describe the freeze-drying rate. Freeze-drying was simulated for two pharmaceuticals with very different properties. Different operational profiles were obtained for the heating and pressure evolution. Differences observed in the pressure evolution derived from the behaviour of the dried layer surrounding the frozen nucleus are discussed. (P.M.T.)
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General Engineering
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book part
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Lombrana , J I , Mijangos , F , Varona , F & Villaran , M C 1991 , Near-optimum heating profiles in freeze-drying in accordance to the transport parameters and product nature . in Unknown Host Publication Title . Amsterdam, The Netherlands, Elsevier Science Publishers .