RT Book, Section T1 Near-optimum heating profiles in freeze-drying in accordance to the transport parameters and product nature A1 Lombrana, J. I. A1 Mijangos, F. A1 Varona, F. A1 Villaran, M. C. AB A simplified mathematical sublimation model is presented to describe the freeze-drying rate. Freeze-drying was simulated for two pharmaceuticals with very different properties. Different operational profiles were obtained for the heating and pressure evolution. Differences observed in the pressure evolution derived from the behaviour of the dried layer surrounding the frozen nucleus are discussed. (P.M.T.) PB Amsterdam, The Netherlands, Elsevier Science Publishers SN 0444893520 SN 9780444893529 YR 1991 FD 1991 LK https://hdl.handle.net/11556/1935 UL https://hdl.handle.net/11556/1935 LA eng NO Lombrana , J I , Mijangos , F , Varona , F & Villaran , M C 1991 , Near-optimum heating profiles in freeze-drying in accordance to the transport parameters and product nature . in Unknown Host Publication Title . Amsterdam, The Netherlands, Elsevier Science Publishers . DS TECNALIA Publications RD 31 jul 2024