"Plasma-click" based strategy for obtaining antibacterial surfaces on implants

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URI: https://hdl.handle.net/11556/3222
ISSN: 1612-8850
DOI: 10.1002/ppap.201200058
Publication date
2013-04
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Abstract
Biomaterials with surface antibacterial properties are promising components for medical implants that might provide an alternative to conventional systemic antibiotic treatments. Herein is reported a general method, based on plasma polymerization techniques, to promote the formation of "clickable surfaces" which can be conjugated with chemically modified antibiotics (e.g., azido-vancomycin) under very mild conditions. The procedure is comprised of three operations: (i) surface alkylcarboxylation with acrylic acid/CO 2 plasma, (ii) alkyne functionalization by condensation with propargylamine, and (iii) in situ Cu(I)-catalyzed alkyne-azide conjugation with azidovancomycin. The antibacterial activity of the resulting functionalized surfaces has been assessed against Staphylococcus epidermidis.
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antibacterial , click chemistry , coating , plasma polymerization , vancomycin , Condensed Matter Physics , Polymers and Plastics
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journal article
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Braceras , I , Oyarbide , J , Azpiroz , P , Briz , N , Ipiñazar , E , Álvarez , N , Atorrasagasti , G , Fratila , R M & Aizpurua , J M 2013 , ' "Plasma-click" based strategy for obtaining antibacterial surfaces on implants ' , Plasma Processes and Polymers , vol. 10 , no. 4 , pp. 328-335 . https://doi.org/10.1002/ppap.201200058