%0 Journal Article
%A Braceras, Iñigo
%A Oyarbide, Joseba
%A Azpiroz, Patxi
%A Briz, Nerea
%A Ipiñazar, Enrique
%A Álvarez, Noelia
%A Atorrasagasti, Garbiñe
%A Fratila, Raluca M.
%A Aizpurua, Jesus M.
%T "Plasma-click" based strategy for obtaining antibacterial surfaces on implants
%D 2013
%@ 1612-8850
%U https://hdl.handle.net/11556/3222
%X Biomaterials with surface antibacterial properties are promising components for medical implants that might provide an alternative to conventional systemic antibiotic treatments. Herein is reported a general method, based on plasma polymerization techniques, to promote the formation of "clickable surfaces" which can be conjugated with chemically modified antibiotics (e.g., azido-vancomycin) under very mild conditions. The procedure is comprised of three operations: (i) surface alkylcarboxylation with acrylic acid/CO 2 plasma, (ii) alkyne functionalization by condensation with propargylamine, and (iii) in situ Cu(I)-catalyzed alkyne-azide conjugation with azidovancomycin. The antibacterial activity of the resulting functionalized surfaces has been assessed against Staphylococcus epidermidis.
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