RT Journal Article
T1 "Plasma-click" based strategy for obtaining antibacterial surfaces on implants
A1 Braceras, Iñigo
A1 Oyarbide, Joseba
A1 Azpiroz, Patxi
A1 Briz, Nerea
A1 Ipiñazar, Enrique
A1 Álvarez, Noelia
A1 Atorrasagasti, Garbiñe
A1 Fratila, Raluca M.
A1 Aizpurua, Jesus M.
AB Biomaterials with surface antibacterial properties are promising components for medical implants that might provide an alternative to conventional systemic antibiotic treatments. Herein is reported a general method, based on plasma polymerization techniques, to promote the formation of "clickable surfaces" which can be conjugated with chemically modified antibiotics (e.g., azido-vancomycin) under very mild conditions. The procedure is comprised of three operations: (i) surface alkylcarboxylation with acrylic acid/CO 2 plasma, (ii) alkyne functionalization by condensation with propargylamine, and (iii) in situ Cu(I)-catalyzed alkyne-azide conjugation with azidovancomycin. The antibacterial activity of the resulting functionalized surfaces has been assessed against Staphylococcus epidermidis.
SN 1612-8850
YR 2013
FD 2013-04
LK https://hdl.handle.net/11556/3222
UL https://hdl.handle.net/11556/3222
LA eng
NO Braceras , I , Oyarbide , J , Azpiroz , P , Briz , N , Ipiñazar , E , Álvarez , N , Atorrasagasti , G , Fratila , R M & Aizpurua , J M 2013 , ' "Plasma-click" based strategy for obtaining antibacterial surfaces on implants ' , Plasma Processes and Polymers , vol. 10 , no. 4 , pp. 328-335 . https://doi.org/10.1002/ppap.201200058
DS TECNALIA Publications
RD 29 jul 2024