Osteoblast response to single wall carbon nanotube-PLLA composites
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2008
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This study showed that incorporation of single-walled carbon nanotubes (1wt%) in to PLLA polymer resulted in a large decrease in resistivity, but did not appear to affect the growth and viability of osteoblast-like cells. Also, incorporation of SWCNTs resulted in no significant difference in alkaline phosphatase activity, an important early-stage marker of osteogenic differentiation, of BMSC. These initial studies suggest that SWCNTs did not have a negative effect on cell behaviour, compared to results reported for MWCNT [2]; this could be related to the purity of CNTs used in the present study. Further, long term studies are required to determine if there is a toxic response to the SWCNTs as the PLLA degrades.
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Annaz , B , Reid , B , Olalde , B , Jurado , M J , Alava , J I , McCaig , C D & Gibson , I R 2008 , Osteoblast response to single wall carbon nanotube-PLLA composites . in 8th World Biomaterials Congress 2008 . 8th World Biomaterials Congress 2008 , vol. 2 , pp. 647 , 8th World Biomaterials Congress 2008, WBC 2008 , Amsterdam , Netherlands , 28/05/08 .
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