Transitions between repetitive tapping and upper limb freezing show impaired movement-related beta band modulation

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URI: https://hdl.handle.net/11556/3528
ISSN: 1388-2457
DOI: 10.1016/j.clinph.2020.05.037
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2020-10
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Abstract
Objective: Freezing phenomena in idiopathic Parkinson's disease (PD) constitute an important unaddressed therapeutic need. Changes in cortical neurophysiological signatures may precede a single freezing episode and indicate the evolution of abnormal motor network processes. Here, we hypothesize that the movement-related power modulation in the beta-band observed during regular finger tapping, deteriorates in the transition period before upper limb freezing (ULF). Methods: We analyzed a 36-channel EEG of 13 patients with PD during self-paced repetitive tapping of the right index finger. In offline analysis, we compared the transition period immediately before ULF (‘transition’) with regular tapping regarding movement-related power modulation and interregional phase synchronization. Results: From time-frequency analyses, we observed that the tap cycle related beta-band power modulation over the left sensorimotor area was diminished in the transition period before ULF. Furthermore, increased beta-band power was observed in the transition period compared to regular tapping centered over the left centro-parietal and right frontal areas. Phase synchronization between the left fronto-parietal areas and the left sensorimotor area was elevated during transition compared to regular tapping. Conclusion: Together, these results indicate that diminished beta band power modulation and increased phase synchronization precede ULF. Significance: We demonstrate that pathological cortical motor processing is present in the transition phase from regular tapping to an ULF episode.
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Publisher Copyright: © 2020 International Federation of Clinical Neurophysiology
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Beta-band modulation , Electrophysiology , Parkinson's disease , Repetitive finger movement , Sensorimotor processing , Upper limb freezing , Sensory Systems , Neurology , Neurology (clinical) , Physiology (medical)
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journal article
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Scholten , M , Schoellmann , A , Ramos-Murguialday , A , López-Larraz , E , Gharabaghi , A & Weiss , D 2020 , ' Transitions between repetitive tapping and upper limb freezing show impaired movement-related beta band modulation ' , Clinical Neurophysiology , vol. 131 , no. 10 , pp. 2499-2507 . https://doi.org/10.1016/j.clinph.2020.05.037