RT Journal Article
T1 Transitions between repetitive tapping and upper limb freezing show impaired movement-related beta band modulation
A1 Scholten, Marlieke
A1 Schoellmann, Anna
A1 Ramos-Murguialday, Ander
A1 López-Larraz, Eduardo
A1 Gharabaghi, Alireza
A1 Weiss, Daniel
AB Objective: Freezing phenomena in idiopathic Parkinson's disease (PD) constitute an important unaddressed therapeutic need. Changes in cortical neurophysiological signatures may precede a single freezing episode and indicate the evolution of abnormal motor network processes. Here, we hypothesize that the movement-related power modulation in the beta-band observed during regular finger tapping, deteriorates in the transition period before upper limb freezing (ULF). Methods: We analyzed a 36-channel EEG of 13 patients with PD during self-paced repetitive tapping of the right index finger. In offline analysis, we compared the transition period immediately before ULF (‘transition’) with regular tapping regarding movement-related power modulation and interregional phase synchronization. Results: From time-frequency analyses, we observed that the tap cycle related beta-band power modulation over the left sensorimotor area was diminished in the transition period before ULF. Furthermore, increased beta-band power was observed in the transition period compared to regular tapping centered over the left centro-parietal and right frontal areas. Phase synchronization between the left fronto-parietal areas and the left sensorimotor area was elevated during transition compared to regular tapping. Conclusion: Together, these results indicate that diminished beta band power modulation and increased phase synchronization precede ULF. Significance: We demonstrate that pathological cortical motor processing is present in the transition phase from regular tapping to an ULF episode.
SN 1388-2457
YR 2020
FD 2020-10
LK https://hdl.handle.net/11556/3528
UL https://hdl.handle.net/11556/3528
LA eng
NO Scholten , M , Schoellmann , A , Ramos-Murguialday , A , López-Larraz , E , Gharabaghi , A & Weiss , D 2020 , ' Transitions between repetitive tapping and upper limb freezing show impaired movement-related beta band modulation ' , Clinical Neurophysiology , vol. 131 , no. 10 , pp. 2499-2507 . https://doi.org/10.1016/j.clinph.2020.05.037
NO Publisher Copyright: © 2020 International Federation of Clinical Neurophysiology
NO Deutsche Forschungsgemeinschaft (DFG) with grant number: WE5375/1-3 .
DS TECNALIA Publications
RD 26 jul 2024