Browsing by Keyword "plasma polymerization"
Now showing 1 - 2 of 2
Results Per Page
Sort Options
Item Plasma polymerized silylated ciprofloxacin as an antibiotic coating(2011-07-22) Braceras, Inigo; Azpiroz, Patxi; Briz, Nerea; Fratila, Raluca M.; Oyarbide, Joseba; Ipiñazar, Enrique; Úlvarez, Noelia; Atorrasagasti, Garbiñe; Aizpurua, Jesus M.; INGENIERÍA DE SUPERFICIES; TECNOLOGÍAS DE HIDRÓGENO; SG; VALORIZACIÓN DE RESIDUOS; BiomaterialesLocally applied antibiotics under temporally controlled release present many advantages over systemic clinical treatments, e.g. efficiency and side effects. This can be achieved by a coating on top of the medical device, in which the antibiotic is stored. This study presents the use of plasma polymerization to produce such a coating using N,O-bis-tert- butyldimethylsilylated ciprofloxacin (silylciprofloxacin) as a precursor. Once exposed to physiological media, the outer layers of the coating release the antibiotic by a hydrolysis reaction. Thus, the plasma process parameters can control the speed of liberation through the coating polymerization. Besides, this study shows that the release products present antibiotic activity against a number of bacteria: E. coli, P. aeruginosa, and S. aureus. Ciprofloxacin release dynamics can be controlled by coating plasma polymerization parameters, allowing local controlled delivery of active antibiotic in physiologic conditions, and thus higher efficiency and lower side effects.Item "Plasma-click" based strategy for obtaining antibacterial surfaces on implants(2013-04) Braceras, Iñigo; Oyarbide, Joseba; Azpiroz, Patxi; Briz, Nerea; Ipiñazar, Enrique; Álvarez, Noelia; Atorrasagasti, Garbiñe; Fratila, Raluca M.; Aizpurua, Jesus M.; INGENIERÍA DE SUPERFICIES; TECNOLOGÍAS DE HIDRÓGENO; SG; VALORIZACIÓN DE RESIDUOS; BiomaterialesBiomaterials with surface antibacterial properties are promising components for medical implants that might provide an alternative to conventional systemic antibiotic treatments. Herein is reported a general method, based on plasma polymerization techniques, to promote the formation of "clickable surfaces" which can be conjugated with chemically modified antibiotics (e.g., azido-vancomycin) under very mild conditions. The procedure is comprised of three operations: (i) surface alkylcarboxylation with acrylic acid/CO 2 plasma, (ii) alkyne functionalization by condensation with propargylamine, and (iii) in situ Cu(I)-catalyzed alkyne-azide conjugation with azidovancomycin. The antibacterial activity of the resulting functionalized surfaces has been assessed against Staphylococcus epidermidis.