Browsing by Author "Olalde, B."
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Item Antiinflammatory eluting system for implantable devices(2008) Madarieta, I.; Ponce, S.; Olalde, B.; Sáez-Martínez, V.; Herrero Vanrell, R.; Molina, I.; Garagorri, N.; Biomateriales; Tecnalia Research & InnovationItem Biomedical applications of ceramic nanocomposites(Elsevier Inc., 2013-07) Garmendia, N.; Olalde, B.; Obieta, I.; Biomateriales; Tecnalia Research & InnovationBioceramics and bioceramic composites have been widely used for biomedical applications for the last 50 years. This chapter discusses the advantages of using ceramic nanocomposites. The application of both inert and bioactive ceramics for orthopaedic and dental implants, as well as in the novel field of tissue engineering, is discussed and future trends are presented.Item Effect of single-walled carbon nanotubes and nano-hydroxyapatite on mechanical properties of PLLA scaffolds(2008) Peris, J. L.; Bermejo, I.; Atienza, C.; Primo, V. J.; Jurado, M. J.; Olalde, B.; Alava, J. I.; Tecnalia Research & Innovation; BiomaterialesItem Guiding migration and differentiation of rat bone marrow stromal cells using d.c. electric fields in vitro - implications in bone tissue engineering(2008-07) Annaz, B.; Reid, B.; Olalde, B.; Jurado, M. J.; Alava, J. I.; Mccaig, C. D.; Gibson, I. R.; Biomateriales; Tecnalia Research & InnovationItem Nanozirconia partially coated MWNT: Nanostructural characerization and cytotoxicity and lixivation study(2008) Garmendia, N.; Bilbao, L.; Muñoz, R.; Goikoetxea, L.; García, A.; Bustero, I.; Olalde, B.; Garagorri, N.; Obieta, I.; PRINTEX; Biomateriales; Tecnalia Research & InnovationCarbon nanotubes could avoid the crack propagation and enhance the toughness of the ceramic material used for prostheses applications. So nanozirconia partially coated carbon nanotubes have been obtained via hydrothermal synthesis of zirconia nanoparticles in presence of multiwall carbon nanotubes. The as covered nanotubes should have a better wettability in the ceramic matrix and improve the dispersion of the CNTs in the nanocomposite, which results in a new ceramic biomaterial with a longer lifetime and better reliability. The obtained product has been structurally characterized by several techniques such as FTIR, XRD, SEM, AFM, EELS, XPS and TGA. The citotoxicity of the sintered product was studied by the change in the pH and ICP-AES in in-vitro biocompatibility tests.Item A novel bioactive scaffold incorporating controlled delivery system(2008) Olalde, B.; Sáez-Martínez, V.; Jurado, M. J.; Garagorri, N.; Biomateriales; Tecnalia Research & InnovationItem Osteoblast response to single wall carbon nanotube-PLLA composites(2008) Annaz, B.; Reid, B.; Olalde, B.; Jurado, M. J.; Alava, J. I.; McCaig, C. D.; Gibson, I. R.; Biomateriales; Tecnalia Research & InnovationThis study showed that incorporation of single-walled carbon nanotubes (1wt%) in to PLLA polymer resulted in a large decrease in resistivity, but did not appear to affect the growth and viability of osteoblast-like cells. Also, incorporation of SWCNTs resulted in no significant difference in alkaline phosphatase activity, an important early-stage marker of osteogenic differentiation, of BMSC. These initial studies suggest that SWCNTs did not have a negative effect on cell behaviour, compared to results reported for MWCNT [2]; this could be related to the purity of CNTs used in the present study. Further, long term studies are required to determine if there is a toxic response to the SWCNTs as the PLLA degrades.Item PLLA plasma surface modifications for selective protein immobilization and improvement interactions with marrow stromal cells(2008) Armentano, I.; Ciapetti, G.; Pennacchi, M.; Dottori, M.; Pagani, S.; Baldini, N.; Olalde, B.; Jurado, M. J.; Alava, I.; Kenny, J. M.; Biomateriales; Tecnalia Research & InnovationItem Sprayed microgels onto 2D and 3D scaffolds as drug eluting coatings(2008) Juan, M. J.; Olalde, B.; Jurado, M. J.; Mattioli, S.; Bilbao, L.; Saez-Martinez, V.; MATERIALES PARA CONDICIONES EXTREMAS; Biomateriales; Tecnalia Research & Innovation; PRINTEXBig advances are being achieved in the design of new implantable devices. Coated scaffolds capable of releasing bioactive agents for inhibiting totally or partially the inflammatory response of the surrounding tissues, are now being regarded as potential useful systems. Polymeric nanoparticles are known to be able to provide a programmable and sustained local drug delivery [1-3]. In addition, biodegradable and biocompatible scaffolds having a highly open porous structure and good mechanical strength are needed to provide an optimal microenvironment for cell proliferation, migration, and differentiation, and guidance for cellular in-growth from host tissue [4]. This study describes preliminary results on a novel coating method using spraying techniques for coating micro-nanometric crosslinked hydrogels on 3D biodegradable scaffolds.