Furxhi, IriniPerucca, MassimoBlosi, MagdaLopez de Ipiña, JesúsOliveira, JulianaMurphy, FinbarrCosta, Anna Luisa2022-01-28Furxhi , I , Perucca , M , Blosi , M , Lopez de Ipiña , J , Oliveira , J , Murphy , F & Costa , A L 2022 , ' ASINA Project: Towards a Methodological Data-Driven Sustainable and Safe-by-Design Approach for the Development of Nanomaterials : Towards a Methodological Data-Driven Sustainable and Safe-by-Design Approach for the Development of Nanomaterials ' , Frontiers in Bioengineering and Biotechnology , vol. 9 , 805096 , pp. 805096 . https://doi.org/10.3389/fbioe.2021.8050962296-4185researchoutputwizard: 11556/1275Publisher Copyright: Copyright © 2022 Furxhi, Perucca, Blosi, Lopez de Ipiña, Oliveira, Murphy and Costa.The novel chemical strategy for sustainability calls for a Sustainable and Safe-by-Design (SSbD) holistic approach to achieve protection of public health and the environment, industrial relevance, societal empowerment, and regulatory preparedness. Based on it, the ASINA project expands a data-driven Management Methodology (ASINA-SMM) capturing quality, safety, and sustainability criteria across the Nano-Enabled Products’ (NEPs) life cycle. We base the development of this methodology through value chains of highly representative classes of NEPs in the market, namely, (i) self-cleaning/air-purifying/antimicrobial coatings and (ii) nano-structured capsules delivering active phases in cosmetics. These NEPs improve environmental quality and human health/wellness and have innovative competence to industrial sectors such as healthcare, textiles, cosmetics, and medical devices. The purpose of this article is to visually exhibit and explain the ASINA approach, which allows identifying, combining, and addressing the following pillars: environmental impact, techno-economic performance, functionality, and human and environmental safety when developing novel NEPs, at an early stage. A metamodel supports the above by utilizing quality data collected throughout the NEPs’ life cycle, for maximization of functionality (to meet stakeholders needs) and nano-safety (regulatory obligations) and for the minimization of costs (to meet business requirements) and environmental impacts (to achieve sustainability). Furthermore, ASINA explores digitalization opportunities (digital twins) to speed the nano-industry translation into automatic progress towards economic, social, environmental, and governance sustainability.12154155enginfo:eu-repo/semantics/openAccessjournal article10.3389/fbioe.2021.805096Safe-by-designSustainable-by-designArtificial intelligenceDigital twinsNanotechnologySafe-by-designSustainable-by-designArtificial intelligenceDigital twinsNanotechnologyBiotechnologyBioengineeringHistologyBiomedical EngineeringSDG 3 - Good Health and Well-beingSDG 8 - Decent Work and Economic GrowthSDG 9 - Industry, Innovation, and InfrastructureProject IDinfo:eu-repo/grantAgreement/EC/H2020/862444/EU/Anticipating Safety Issues at the Design Stage of NAno Product Development/ASINAinfo:eu-repo/grantAgreement/EC/H2020/862444/EU/Anticipating Safety Issues at the Design Stage of NAno Product Development/ASINAFunding InfoThis research was funded by the European Union’s Horizon 2020 research and innovation programme under grant agreement No 862444This research was funded by the European Union’s Horizon 2020 research and innovation programme under grant agreement No 862444http://www.scopus.com/inward/record.url?scp=85124608125&partnerID=8YFLogxK