Braceras, IñigoOyarbide, JosebaAzpiroz, PatxiBriz, NereaIpiñazar, EnriqueÁlvarez, NoeliaAtorrasagasti, GarbiñeFratila, Raluca M.Aizpurua, Jesus M.2024-07-242024-07-242013-04Braceras , I , Oyarbide , J , Azpiroz , P , Briz , N , Ipiñazar , E , Álvarez , N , Atorrasagasti , G , Fratila , R M & Aizpurua , J M 2013 , ' "Plasma-click" based strategy for obtaining antibacterial surfaces on implants ' , Plasma Processes and Polymers , vol. 10 , no. 4 , pp. 328-335 . https://doi.org/10.1002/ppap.2012000581612-8850https://hdl.handle.net/11556/3222Biomaterials with surface antibacterial properties are promising components for medical implants that might provide an alternative to conventional systemic antibiotic treatments. Herein is reported a general method, based on plasma polymerization techniques, to promote the formation of "clickable surfaces" which can be conjugated with chemically modified antibiotics (e.g., azido-vancomycin) under very mild conditions. The procedure is comprised of three operations: (i) surface alkylcarboxylation with acrylic acid/CO 2 plasma, (ii) alkyne functionalization by condensation with propargylamine, and (iii) in situ Cu(I)-catalyzed alkyne-azide conjugation with azidovancomycin. The antibacterial activity of the resulting functionalized surfaces has been assessed against Staphylococcus epidermidis.8enginfo:eu-repo/semantics/restrictedAccessjournal article10.1002/ppap.201200058antibacterialclick chemistrycoatingplasma polymerizationvancomycinCondensed Matter PhysicsPolymers and Plasticshttp://www.scopus.com/inward/record.url?scp=84876011165&partnerID=8YFLogxK