De Maeztu, M. A.Braceras, I.Álava, J. I.Recio, C.Piñera, M.Gay-Escoda, C.2024-07-242024-07-242013-07De Maeztu , M A , Braceras , I , Álava , J I , Recio , C , Piñera , M & Gay-Escoda , C 2013 , ' Human study of ion implantation as a surface treatment for dental implants ' , International Journal of Oral and Maxillofacial Surgery , vol. 42 , no. 7 , pp. 891-896 . https://doi.org/10.1016/j.ijom.2013.02.0200901-5027https://hdl.handle.net/11556/3504This clinical study evaluated a new surface treatment of ion implantation with CO ions which has previously been subjected to extensive study in animal models. The aim of this work was to assess its effect in humans. Experimental mini-implants were used; half of their longitudinal surface was machined and the other half was treated with CO ion implantation. The study was conducted in healthy volunteer patients who required prosthetic treatment with dental implants, and in accordance with the corresponding ethics committees. Coinciding with the insertion of commercial implants for oral restoration, one or two mini-implants were placed in the upper maxillary tuberosity or in the retromolar trigone of the mandible. The mini-implants were removed with a trephine jointly with a small volume of surrounding bone after a 3-month period. Two evaluation methods were used and both showed a greater degree of bone integration in the mini-implant section that underwent CO ion implantation treatment in comparison with the non-treated surface: 62.9% vs. 57.9%, and 54.8% vs. 46.2%. In addition, no adverse reactions were observed in the surface treatment with CO ion implantation. These results confirm the positive benefits in humans, based on the findings obtained from previous animal experiments.6enginfo:eu-repo/semantics/restrictedAccessjournal article10.1016/j.ijom.2013.02.020clinical studyCO ion implantationdental implantshistomorphometric studymini-implantssurface treatmentsSurgeryOral SurgeryOtorhinolaryngologyhttp://www.scopus.com/inward/record.url?scp=84878472438&partnerID=8YFLogxK