RT Journal Article
T1 Ion implantation induced nanotopography on titanium and bone cell adhesion
A1 Braceras, Iñigo
A1 Vera, Carolina
A1 Ayerdi-Izquierdo, Ana
A1 Muñoz, Roberto
A1 Lorenzo, Jaione
A1 Alvarez, Noelia
A1 De Maeztu, Miguel Ángel
AB Permanent endo-osseous implants require a fast, reliable and consistent osseointegration, i.e. intimate bonding between bone and implant, so biomechanical loads can be safely transferred. Among the parameters that affect this process, it is widely admitted that implant surface topography, surface energy and composition play an important role. Most surface treatments to improve osseointegration focus on micro-scale features, as few can effectively control the effects of the treatment at nanoscale. On the other hand, ion implantation allows controlling such nanofeatures. This study has investigated the nanotopography of titanium, as induced by different ion implantation surface treatments, its similarity with human bone tissue structure and its effect on human bone cell adhesion, as a first step in the process of osseointegration. The effect of ion implantation treatment parameters such as energy (40-80 keV), fluence (1-2 e17 ion/cm 2 ) and ion species (Kr, Ar, Ne and Xe) on the nanotopography of medical grade titanium has been measured and assessed by AFM and contact angle. Then, in vitro tests have been performed to assess the effect of these nanotopographies on osteoblast adhesion. The results have shown that the nanostructure of bone and the studied ion implanted surfaces, without surface chemistry modification, are in the same range and that such modifications, in certain conditions, do have a statistically significant effect on bone tissue forming cell adhesion.
SN 0169-4332
YR 2014
FD 2014-08-15
LK https://hdl.handle.net/11556/3664
UL https://hdl.handle.net/11556/3664
LA eng
NO Braceras , I , Vera , C , Ayerdi-Izquierdo , A , Muñoz , R , Lorenzo , J , Alvarez , N & De Maeztu , M Á 2014 , ' Ion implantation induced nanotopography on titanium and bone cell adhesion ' , Applied Surface Science , vol. 310 , pp. 24-30 . https://doi.org/10.1016/j.apsusc.2014.03.118
NO The work was financially supported by the ETORTEK BIOSUPERFICIES , Basque Government IE07-201 research programme and the NACRE project of the Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN) .
DS TECNALIA Publications
RD 30 jul 2024