RT Journal Article
T1 Non-invasive brain-spine interface: 												Continuous control of trans-spinal magnetic stimulation using EEG
A1 Insausti-Delgado, Ainhoa
A1 López-Larraz, Eduardo
A1 Nishimura, Yukio
A1 Ziemann, Ulf
A1 Ramos-Murguialday, Ander
AB Brain-controlled neuromodulation has emerged as a promising tool to promote functional recovery in patients with motor disorders. Brain-machine interfaces exploit this neuromodulatory strategy and could be used for restoring voluntary control of lower limbs. In this work, we propose a non-invasive brain-spine interface (BSI) that processes electroencephalographic (EEG) activity to volitionally control trans-spinal magnetic stimulation (ts-MS), as an approach for lower-limb neurorehabilitation. This novel platform allows to contingently connect motor cortical activation during leg motor imagery with the activation of leg muscles via ts-MS. We tested this closed-loop system in 10 healthy participants using different stimulation conditions. This BSI efficiently removed stimulation artifacts from EEG regardless of ts-MS intensity used, allowing continuous monitoring of cortical activity and real-time closed-loop control of ts-MS. Our BSI induced afferent and efferent evoked responses, being this activation ts-MS intensity-dependent. We demonstrated the feasibility, safety and usability of this non-invasive BSI. The presented system represents a novel non-invasive means of brain-controlled neuromodulation and opens the door towards its integration as a therapeutic tool for lower-limb rehabilitation.
SN 2296-4185
YR 2022
FD 2022-10-31
LA eng
NO Insausti-Delgado , A , López-Larraz , E , Nishimura , Y , Ziemann , U & Ramos-Murguialday , A 2022 , ' Non-invasive brain-spine interface : Continuous control of trans-spinal magnetic stimulation using EEG ' , Frontiers in Bioengineering and Biotechnology , vol. 10 , 975037 . https://doi.org/10.3389/fbioe.2022.975037
NO Publisher Copyright: Copyright © 2022 Insausti-Delgado, López-Larraz, Nishimura, Ziemann and Ramos-Murguialday.
NO This study was funded by the Eureka-Eurostars program (SubliminalHomeRehab (E! 113928)), the Fortüne-Program of the University of Tübingen (2422-0-1 and 2556-0-0 to ELL), the Junior Research Group program inside the Fortüne-Funding of the University of Tübingen (2452-0-0 to ARM), and the ELKARTEK funding program of the Basque Government (BIOSTIM KK-2021/0096). AID was funded by the Basque Government’s scholarship for predoctoral students.
DS TECNALIA Publications
RD 27 sept 2024