RT Journal Article T1 ASINA Project: Towards a Methodological Data-Driven Sustainable and Safe-by-Design Approach for the Development of Nanomaterials: Towards a Methodological Data-Driven Sustainable and Safe-by-Design Approach for the Development of Nanomaterials A1 Furxhi, Irini A1 Perucca, Massimo A1 Blosi, Magda A1 Lopez de Ipiña, Jesús A1 Oliveira, Juliana A1 Murphy, Finbarr A1 Costa, Anna Luisa AB The novel chemical strategy for sustainability calls for a Sustainable and Safe-by-Design (SSbD) holistic approach to achieve protection of public health and the environment, industrial relevance, societal empowerment, and regulatory preparedness. Based on it, the ASINA project expands a data-driven Management Methodology (ASINA-SMM) capturing quality, safety, and sustainability criteria across the Nano-Enabled Products’ (NEPs) life cycle. We base the development of this methodology through value chains of highly representative classes of NEPs in the market, namely, (i) self-cleaning/air-purifying/antimicrobial coatings and (ii) nano-structured capsules delivering active phases in cosmetics. These NEPs improve environmental quality and human health/wellness and have innovative competence to industrial sectors such as healthcare, textiles, cosmetics, and medical devices. The purpose of this article is to visually exhibit and explain the ASINA approach, which allows identifying, combining, and addressing the following pillars: environmental impact, techno-economic performance, functionality, and human and environmental safety when developing novel NEPs, at an early stage. A metamodel supports the above by utilizing quality data collected throughout the NEPs’ life cycle, for maximization of functionality (to meet stakeholders needs) and nano-safety (regulatory obligations) and for the minimization of costs (to meet business requirements) and environmental impacts (to achieve sustainability). Furthermore, ASINA explores digitalization opportunities (digital twins) to speed the nano-industry translation into automatic progress towards economic, social, environmental, and governance sustainability. SN 2296-4185 YR 2022 FD 2022-01-28 LA eng NO Furxhi , I , Perucca , M , Blosi , M , Lopez de Ipiña , J , Oliveira , J , Murphy , F & Costa , A L 2022 , ' ASINA Project: Towards a Methodological Data-Driven Sustainable and Safe-by-Design Approach for the Development of Nanomaterials : Towards a Methodological Data-Driven Sustainable and Safe-by-Design Approach for the Development of Nanomaterials ' , Frontiers in Bioengineering and Biotechnology , vol. 9 , 805096 , pp. 805096 . https://doi.org/10.3389/fbioe.2021.805096 NO Publisher Copyright: Copyright © 2022 Furxhi, Perucca, Blosi, Lopez de Ipiña, Oliveira, Murphy and Costa. DS TECNALIA Publications RD 3 jul 2024