RT Journal Article
T1 Fragmentation of slow wave sleep after onset of complete locked-in state
A1 Soekadar, Surjo R.
A1 Born, Jan
A1 Birbaumer, Niels
A1 Bensch, Michael
A1 Halder, Sebastian
A1 Murguialday, Ander Ramos
A1 Gharabaghi, Alireza
A1 Nijboer, Femke
A1 Schol̈kopf, Bernhard
A1 Martens, Suzanne
AB Locked-in syndrome (LIS) as a result of brainstem lesions or progressive neurodegenerative disorders, such as amyotrophic lateral sclerosis (ALS), is a severe medical condition in which a person is fully conscious but unable to move or talk. LIS can transition into complete locked-in syndrome (CLIS) in which residual abilities to communicate through muscle twitches are entirely lost. It is unknown how CLIS affects circadian rhythm and sleep/wake patterns. Here we report a 39-year-old ALS patient who transitioned from LIS to CLIS while brain activity was continuously recorded using electrocorticography (ECoG) over one month. While we found no circadian rhythm in heart rate and body temperature, transition into CLIS was associated with increased fragmentation of slow wave sleep (SWS) across the day. Total time in SWS did not change. SWS fragmentation might refl ect progressive circadian system impairment and should be considered as a factor further limiting communication capabilities in these patients.
SN 1550-9389
YR 2013
FD 2013
LK https://hdl.handle.net/11556/4238
UL https://hdl.handle.net/11556/4238
LA eng
NO Soekadar , S R , Born , J , Birbaumer , N , Bensch , M , Halder , S , Murguialday , A R , Gharabaghi , A , Nijboer , F , Schol̈kopf , B & Martens , S 2013 , ' Fragmentation of slow wave sleep after onset of complete locked-in state ' , Journal of Clinical Sleep Medicine , vol. 9 , no. 9 , pp. 951-953 . https://doi.org/10.5664/jcsm.3002
DS TECNALIA Publications
RD 26 jul 2024