RT Journal Article
T1 Effect of nanotubes and apatite on growth factor release from PLLA scaffolds
A1 Zande, Meike van der
A1 Walboomers, X. Frank
A1 Olalde, Beatriz
A1 Jurado, Maria J.
A1 Álava, J. Iñaki
A1 Boerman, Otto C.
A1 Jansen, John A.
AB There is an evident clinical need for artificial bone restorative materials. In this respect, novel composites based on poly(L-lactic acid) (PLLA) have been described. The bone response of such polymer-based composites is usually improved by the addition of bone morphogenetic protein-2 (BMP-2). However, released BMP-2 is cleared almost immediately from the site of implantation by diffusion, whereas a prolonged retention of BMP-2 onto the scaffold has been suggested to be more favourable. Besides the ability to improve the mechanical strength and osteoconductivity of polymeric scaffolds, both carbon nanotubes (CNTs) and microhydroxyapatite (μHA) have been described to facilitate such retention of BMP-2 when incorporated into a composite scaffold. Therefore, in the current study, radiolabelled BMP-2 was loaded onto plain PLLA and composite PLLA-CNT-μHA scaffolds. Subsequently, the scaffolds were implanted subcutaneously for 5 weeks in rats and BMP-2 release was measured. Release started with an initial phase of quick release, followed by a gradual release of BMP-2. Both scaffold types comprised the same in vivo release properties for BMP-2. The bioactivity of the BMP-2 remained unaltered. It can be concluded that incorporated CNTs and μHA did not affect BMP-2 release from composite scaffold materials.
SN 1932-6254
YR 2011
FD 2011-06
LK https://hdl.handle.net/11556/4140
UL https://hdl.handle.net/11556/4140
LA eng
NO Zande , M V D , Walboomers , X F , Olalde , B , Jurado , M J , Álava , J I , Boerman , O C & Jansen , J A 2011 , ' Effect of nanotubes and apatite on growth factor release from PLLA scaffolds ' , Journal of Tissue Engineering and Regenerative Medicine , vol. 5 , no. 6 , pp. 476-482 . https://doi.org/10.1002/term.339
DS TECNALIA Publications
RD 30 jul 2024