RT Journal Article
T1 Numerical simulation of iontophoresis in the drug delivery system
A1 Filipovic, Nenad
A1 Zivanovic, Marko
A1 Savic, Andrej
A1 Bijelic, Goran
AB The architecture and composition of stratum corneum act as barriers and limit the diffusion of most drug molecules and ions. Much effort has been made to overcome this barrier and it can be seen that iontophoresis has shown a good effect. Iontophoresis represents the application of low electrical potential to increase the transport of drugs into and across the skin or tissue. Iontophoresis is a noninvasive drug delivery system, and therefore, it is a useful alternative to drug transportation by injection. In this study, we present a numerical model and effects of electrical potential on the drug diffusion in the buccal tissue and the stratum corneum. The initial numerical results are in good comparison with experimental observation. We demonstrate that the application of an applied voltage can greatly improve the efficacy of localized drug delivery as compared to diffusion alone.
SN 1025-5842
YR 2016
FD 2016-08-17
LA eng
NO Filipovic , N , Zivanovic , M , Savic , A & Bijelic , G 2016 , ' Numerical simulation of iontophoresis in the drug delivery system ' , Computer Methods in Biomechanics and Biomedical Engineering , vol. 19 , no. 11 , pp. 1154-1159 . https://doi.org/10.1080/10255842.2015.1115021
NO Publisher Copyright: © 2015 Taylor & Francis.
DS TECNALIA Publications
RD 26 jul 2024