RT Journal Article
T1 Assessing attention and cognitive function in completely locked-in state with event-related brain potentials and epidural electrocorticography
A1 Bensch, Michael
A1 Martens, Suzanne
A1 Halder, Sebastian
A1 Hill, Jeremy
A1 Nijboer, Femke
A1 Ramos, Ander
A1 Birbaumer, Niels
A1 Bogdan, Martin
A1 Kotchoubey, Boris
A1 Rosenstiel, Wolfgang
A1 Schölkopf, Bernhard
A1 Gharabaghi, Alireza
AB Objective. Patients in the completely locked-in state (CLIS), due to, for example, amyotrophic lateral sclerosis (ALS), no longer possess voluntary muscle control. Assessing attention and cognitive function in these patients during the course of the disease is a challenging but essential task for both nursing staff and physicians. Approach. An electrophysiological cognition test battery, including auditory and semantic stimuli, was applied in a late-stage ALS patient at four different time points during a six-month epidural electrocorticography (ECoG) recording period. Event-related cortical potentials (ERP), together with changes in the ECoG signal spectrum, were recorded via 128 channels that partially covered the left frontal, temporal and parietal cortex. Main results. Auditory but not semantic stimuli induced significant and reproducible ERP projecting to specific temporal and parietal cortical areas. N1/P2 responses could be detected throughout the whole study period. The highest P3 ERP was measured immediately after the patient's last communication through voluntary muscle control, which was paralleled by low theta and high gamma spectral power. Three months after the patient's last communication, i.e., in the CLIS, P3 responses could no longer be detected. At the same time, increased activity in low-frequency bands and a sharp drop of gamma spectral power were recorded. Significance. Cortical electrophysiological measures indicate at least partially intact attention and cognitive function during sparse volitional motor control for communication. Although the P3 ERP and frequency-specific changes in the ECoG spectrum may serve as indicators for CLIS, a close-meshed monitoring will be required to define the exact time point of the transition.
SN 1741-2560
YR 2014
FD 2014-04
LK https://hdl.handle.net/11556/2944
UL https://hdl.handle.net/11556/2944
LA eng
NO Bensch , M , Martens , S , Halder , S , Hill , J , Nijboer , F , Ramos , A , Birbaumer , N , Bogdan , M , Kotchoubey , B , Rosenstiel , W , Schölkopf , B & Gharabaghi , A 2014 , ' Assessing attention and cognitive function in completely locked-in state with event-related brain potentials and epidural electrocorticography ' , Journal of Neural Engineering , vol. 11 , no. 2 , 026006 . https://doi.org/10.1088/1741-2560/11/2/026006
DS TECNALIA Publications
RD 26 jul 2024