RT Journal Article
T1 Brain-Machine Interface in Chronic Stroke: 												Randomized Trial Long-Term Follow-up
A1 Ramos-Murguialday, Ander
A1 Curado, Marco R.
A1 Broetz, Doris
A1 Yilmaz, Özge
A1 Brasil, Fabricio L.
A1 Liberati, Giulia
A1 Garcia-Cossio, Eliana
A1 Cho, Woosang
A1 Caria, Andrea
A1 Cohen, Leonardo G.
A1 Birbaumer, Niels
AB Background. Brain-machine interfaces (BMIs) have been recently proposed as a new tool to induce functional recovery in stroke patients. Objective. Here we evaluated long-term effects of BMI training and physiotherapy in motor function of severely paralyzed chronic stroke patients 6 months after intervention. Methods. A total of 30 chronic stroke patients with severe hand paresis from our previous study were invited, and 28 underwent follow-up assessments. BMI training included voluntary desynchronization of ipsilesional EEG-sensorimotor rhythms triggering paretic upper-limb movements via robotic orthoses (experimental group, n = 16) or random orthoses movements (sham group, n = 12). Both groups received identical physiotherapy following BMI sessions and a home-based training program after intervention. Upper-limb motor assessment scores, electromyography (EMG), and functional magnetic resonance imaging (fMRI) were assessed before (Pre), immediately after (Post1), and 6 months after intervention (Post2). Results. The experimental group presented with upper-limb Fugl-Meyer assessment (cFMA) scores significantly higher in Post2 (13.44 ± 1.96) as compared with the Pre session (11.16 ± 1.73; P =.015) and no significant changes between Post1 and Post2 sessions. The Sham group showed no significant changes on cFMA scores. Ashworth scores and EMG activity in both groups increased from Post1 to Post2. Moreover, fMRI-BOLD laterality index showed no significant difference from Pre or Post1 to Post2 sessions. Conclusions. BMI-based rehabilitation promotes long-lasting improvements in motor function of chronic stroke patients with severe paresis and represents a promising strategy in severe stroke neurorehabilitation.
SN 1545-9683
YR 2019
FD 2019-03
LA eng
NO Ramos-Murguialday , A , Curado , M R , Broetz , D , Yilmaz , Ö , Brasil , F L , Liberati , G , Garcia-Cossio , E , Cho , W , Caria , A , Cohen , L G & Birbaumer , N 2019 , ' Brain-Machine Interface in Chronic Stroke : Randomized Trial Long-Term Follow-up ' , Neurorehabilitation and Neural Repair , vol. 33 , no. 3 , pp. 188-198 . https://doi.org/10.1177/1545968319827573
NO Publisher Copyright: © The Author(s) 2019.
DS TECNALIA Publications
RD 26 jul 2024