RT Journal Article
T1 Modeling neural differentiation on micropatterned substrates coated with neural matrix components
A1 García-Parra, Patricia
A1 Cavaliere, Fabio
A1 Maroto, Marcos
A1 Bilbao, Leire
A1 Obieta, Isabel
A1 de Munain, Adolfo López
A1 Álava, José Iñaki
A1 Izeta, Ander
AB Topographical and biochemical characteristics of the substrate are critical for neuronal differentiation including axonal outgrowth and regeneration of neural circuits in vivo. Contact stimuli and signaling molecules allow neurons to develop and stabilize synaptic contacts. Here we present the development, characterization and functional validation of a new polymeric support able to induce neuronal differentiation in both PC12 cell line and adult primary skin-derived precursor cells (SKPs) in vitro. By combining a photolithographic technique with use of neural extracellular matrix (ECM) as a substrate, a biocompatible and efficient microenvironment for neuronal differentiation was developed.
SN 1662-5102
YR 2012
FD 2012-03-14
LK https://hdl.handle.net/11556/3072
UL https://hdl.handle.net/11556/3072
LA eng
NO García-Parra , P , Cavaliere , F , Maroto , M , Bilbao , L , Obieta , I , de Munain , A L , Álava , J I & Izeta , A 2012 , ' Modeling neural differentiation on micropatterned substrates coated with neural matrix components ' , Frontiers in Cellular Neuroscience , no. MARCH , 10 . https://doi.org/10.3389/fncel.2012.00010
DS TECNALIA Publications
RD 26 jul 2024