RT Journal Article
T1 Bacterial adhesion reduction on a biocompatible Si+ ion implanted austenitic stainless steel
A1 Gallardo-Moreno, A. M.
A1 Multigner, M.
A1 Calzado-Martín, A.
A1 Méndez-Vilas, A.
A1 Saldaña, L.
A1 Galván, J. C.
A1 Pacha-Olivenza, M. A.
A1 Perera-Núñez, J.
A1 González-Carrasco, J. L.
A1 Braceras, I.
A1 Vilaboa, N.
A1 González-Martín, M. L.
AB The colonization of an implant surface by bacteria is an extremely important medical problem, which often leads to the failure of medical devices. Modern surface modification techniques, such as ion implantation, can confer to the surfaces very different properties from those of the bulk underlying material. In this work, austenitic stainless steel 316 LVM has been superficially modified by Si+ ion implantation. The effect of surface modification on the biocompatibility and bacterial adhesion to 316 LVM stainless steel has been investigated. To this aim, human mesenchymal stem cells (hMSCs), as precursor of osteoblastic cells, and bacterial strains relevant in infections related to orthopedic implants, i.e., Staphylococcus aureus and Staphylococcus epidermidis, have been assayed. For the understanding of changes in the biological response associated to ion implantation, variations in the chemical surface composition, topography, surface Gibbs energy, isoelectric point and in vitro corrosion behavior have been evaluated. hMSCs adhesion, viability and differentiation to the osteoblastic lineage were unaffected by Si+ ion implantation. On the other hand, Si+ ion implantation diminished the number of attached bacteria in static conditions and led to smaller adhesion rates and retention strength. The ability of implanted surfaces to reduce the bacterial adhesion was higher for Staphylococcus epidermidis than for Staphylococcus aureus. This study proposes Si+ ion implantation as an effective way of reducing bacterial adhesion on 316 LVM stainless steel surfaces without compromising its good biocompatibility.
SN 0928-4931
YR 2011
FD 2011-10-10
LK https://hdl.handle.net/11556/4364
UL https://hdl.handle.net/11556/4364
LA eng
NO Gallardo-Moreno , A M , Multigner , M , Calzado-Martín , A , Méndez-Vilas , A , Saldaña , L , Galván , J C , Pacha-Olivenza , M A , Perera-Núñez , J , González-Carrasco , J L , Braceras , I , Vilaboa , N & González-Martín , M L 2011 , ' Bacterial adhesion reduction on a biocompatible Si + ion implanted austenitic stainless steel ' , Materials Science and Engineering C , vol. 31 , no. 7 , pp. 1567-1576 . https://doi.org/10.1016/j.msec.2011.07.008
NO The authors wish to express their thanks for the financial support of Grants Nos. MAT2006-12948-C04-(01-02-03) , MAT2009-14695-C04-(01-02-03) and CIT-420000-2008-17 from Ministerio de Ciencia e Innovación (Spain Government) , grant PRI08A124 and GRU09124 from the Junta de Extremadura (Extremadura Regional Government) , and grants from Fundación Mutua Madrileña . NV is supported by program I3SNS from Fondo de Investigaciones Sanitarias (Spain) . MLGM is granted by program I3 from Ministerio de Ciencia e Innovación and Junta de Extremadura . The CACTI service (Vigo, Spain) is acknowledged for XPS analysis and the CAI (UCM, Madrid, Spain) for ion implantation.
DS TECNALIA Publications
RD 30 jul 2024