RT Journal Article
T1 Novel Concept of Micro Patterned Micro Titer Plates Fabricated via UV-NIL for Automated Neuronal Cell Assay Read-Out
A1 Lohse, Mirko
A1 Thesen, Manuel W.
A1 Haase, Anja
A1 Smolka, Martin
A1 Iceta, Nerea Briz
A1 Ayerdi Izquierdo, Ana
A1 Ramos, Isbaal
A1 Salado, Clarisa
A1 Schleunitz, Arne
AB The UV-nanoimprint lithography(UV-NIL) fabrication of a novel network of micron-sized channels, forming an open channel microfluidic system is described. Details about the complete manufacturing process, from mastering to fabrication in small batches and in high throughput with up to 1200 micro titer plates per hour is presented. Deep insight into the evaluation of a suitable UV-curable material, mr-UVCur26SF is given, presenting cytotoxic evaluation, cell compatibility tests and finally a neuronal assay. The results indicate how the given pattern, in combination with the resist, paves the way to faster, cheaper, and more reliable drug screening.
SN 2079-4991
YR 2021
FD 2021-04-01
LA eng
NO Lohse , M , Thesen , M W , Haase , A , Smolka , M , Iceta , N B , Ayerdi Izquierdo , A , Ramos , I , Salado , C & Schleunitz , A 2021 , ' Novel Concept of Micro Patterned Micro Titer Plates Fabricated via UV-NIL for Automated Neuronal Cell Assay Read-Out ' , Nanomaterials , vol. 11 , no. 4 , 902 , pp. 902 . https://doi.org/10.3390/nano11040902
NO Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
DS TECNALIA Publications
RD 3 jul 2024