RT Journal Article
T1 Prevention of diabetes in overweight/obese children through a family based intervention program including supervised exercise (PREDIKID project): study protocol for a randomized controlled trial: 												Study protocol for a randomized controlled trial
A1 Arenaza, Lide
A1 Medrano, María
A1 Amasene, María
A1 Rodríguez-Vigil, Beatriz
A1 Díez, Ignacio
A1 Graña, Manuel
A1 Tobalina, Ignacio
A1 Maiz, Edurne
A1 Arteche, Edurne
A1 Larrarte, Eider
A1 Huybrechts, Inge
A1 Davis, Catherine L.
A1 Ruiz, Jonatan R.
A1 Ortega, Francisco B.
A1 Margareto, Javier
A1 Labayen, Idoia
AB Background: The global pandemic of obesity has led to an increased risk for prediabetes and type-2 diabetes (T2D). The aims of the current project are: (1) to evaluate the effect of a 22-week family based intervention program, including supervised exercise, on insulin resistance syndrome (IRS) risk in children with a high risk of developing T2D and (2) to identify the profile of microRNA in circulating exosomes and in peripheral blood mononuclear cells in children with a high risk of developing T2D and its response to a multidisciplinary intervention program including exercise. Methods: A total of 84 children, aged 8-12 years, with a high risk of T2D will be included and randomly assigned to control (N = 42) or intervention (N = 42) groups. The control group will receive a family based lifestyle education and psycho-educational program (2 days/month), while the intervention group will attend the same lifestyle education and psycho-educational program plus the exercise program (3 days/week, 90 min per session including warm-up, moderate to vigorous aerobic activities, and strength exercises). The following measurements will be evaluated at baseline prior to randomization and after the intervention: fasting insulin, glucose and hemoglobin A1c; body composition (dual-energy X-ray absorptiometry); ectopic fat (magnetic resonance imaging); microRNA expression in circulating exosomes and in peripheral blood mononuclear cells (MiSeq; Illumina); cardiorespiratory fitness (cardiopulmonary exercise testing); dietary habits and physical activity (accelerometry). Discussion: Prevention and identification of children with a high risk of developing T2D could help to improve their cardiovascular health and to reduce the comorbidities associated with obesity.
SN 1745-6215
YR 2017
FD 2017-08-10
LA eng
NO Arenaza , L , Medrano , M , Amasene , M , Rodríguez-Vigil , B , Díez , I , Graña , M , Tobalina , I , Maiz , E , Arteche , E , Larrarte , E , Huybrechts , I , Davis , C L , Ruiz , J R , Ortega , F B , Margareto , J & Labayen , I 2017 , ' Prevention of diabetes in overweight/obese children through a family based intervention program including supervised exercise (PREDIKID project): study protocol for a randomized controlled trial : Study protocol for a randomized controlled trial ' , Trials , vol. 18 , no. 1 , 372 . https://doi.org/10.1186/s13063-017-2117-y
NO Publisher Copyright: © 2017 The Author(s).
DS TECNALIA Publications
RD 3 jul 2024