RT Journal Article
T1 Brain–Machine Interface Induced Morpho-Functional Remodeling of the Neural Motor System in Severe Chronic Stroke
A1 Caria, Andrea
A1 da Rocha, Josué Luiz Dalboni
A1 Gallitto, Giuseppe
A1 Birbaumer, Niels
A1 Sitaram, Ranganatha
A1 Murguialday, Ander Ramos
AB Brain–machine interfaces (BMI) permit bypass motor system disruption by coupling contingent neuroelectric signals related to motor activity with prosthetic devices that enhance afferent and proprioceptive feedback to the somatosensory cortex. In this study, we investigated neural plasticity in the motor network of severely impaired chronic stroke patients after an EEG-BMI-based treatment reinforcing sensorimotor contingency of ipsilesional motor commands. Our structural connectivity analysis revealed decreased fractional anisotropy in the splenium and body of the corpus callosum, and in the contralesional hemisphere in the posterior limb of the internal capsule, the posterior thalamic radiation, and the superior corona radiata. Functional connectivity analysis showed decreased negative interhemispheric coupling between contralesional and ipsilesional sensorimotor regions, and decreased positive intrahemispheric coupling among contralesional sensorimotor regions. These findings indicate that BMI reinforcing ipsilesional brain activity and enhancing proprioceptive function of the affected hand elicits reorganization of contralesional and ipsilesional somatosensory and motor-assemblies as well as afferent and efferent connection–related motor circuits that support the partial re-establishment of the original neurophysiology of the motor system even in severe chronic stroke.
SN 1933-7213
YR 2020
FD 2020-04-01
LK https://hdl.handle.net/11556/4026
UL https://hdl.handle.net/11556/4026
LA eng
NO Caria , A , da Rocha , J L D , Gallitto , G , Birbaumer , N , Sitaram , R & Murguialday , A R 2020 , ' Brain–Machine Interface Induced Morpho-Functional Remodeling of the Neural Motor System in Severe Chronic Stroke ' , Neurotherapeutics , vol. 17 , no. 2 , pp. 635-650 . https://doi.org/10.1007/s13311-019-00816-2
NO Publisher Copyright: © 2019, The American Society for Experimental NeuroTherapeutics, Inc.
NO This work was supported by the German Federal Ministry of Education and Research (BMBF, Förderzeichen 01GQ0831); Deutsche Forschungsgemeinschaft (DFG) Koselleck (BI 195/58-1); European Research Council (ERC 227632); European Union FP7-ICT-2009-231724 - HUMOR: Human Behavioral Modeling for Enhancing Learning by Optimizing Human-Robot Interaction, FP7-ICT-2009-247935 – BETTER: BNCI-driven Robotic Physical Therapies in Stroke Rehabilitation of Gait Disorders; Italian Ministry of Health GR-2009-159190; BW-Stiftung (ROB-1); Werner Reichardt Centre for Integrative Neuroscience (CIN). The authors would like to thank Balint Varkuti, Leonhard Läer, Pavel Terekhin, Nicolas Lindau, and Bjorn Schiffler for their support.
DS TECNALIA Publications
RD 26 jul 2024