RT Journal Article T1 Is cardiorespiratory fitness independently associated with the biochemical profile in overweight/obese adults with primary hypertension? The EXERDIET-HTA study A1 Corres, Pablo A1 Maldonado-Martín, Sara A1 Gorostegi-Anduaga, Ilargi A1 Fryer, Simon M. A1 Jurio-Iriarte, Borja A1 MartínezAguirre-Betolaza, Aitor A1 Arratibel-Imaz, Iñaki A1 Francisco-Terreros, Silvia A1 Pérez-Asenjo, Javier AB Cardiorespiratory fitness (CRF) is positively associated with enhanced cardiovascular health. This cross-sectional study aimed to determine associations between CRF and the biochemical profile of overweight/obese adults diagnosed with primary hypertension (HTN). Does cardiorespiratory fitness (exposure) positively affect the biochemical profile (outcome) in overweight/obese individuals suffering from HTN? Assessment with anthropometric, ambulatory blood pressure monitoring (24 h), CRF (peak oxygen uptake, V̇O 2peak ) and biochemical analysis was performed on 214 participants (138 men, 76 women). A series of linear and logistic regression analyses were conducted. Participants were divided into CRF tertiles (classified as low, moderate and high CRF). The CRF was independently and inversely associated with aspartate aminotransferase (AST; β = −0.328, p <.05) and alanine aminotransferase (ALT; β = −0.376, p <.01) concentrations. C-reactive protein, AST/ALT ratio, gamma-glutamyl transpeptidase, total cholesterol/high-density lipoprotein cholesterol ratio, glucose, insulin and insulin resistance index (HOMA-IR), were all associated, but not independently, with CRF in linear and/or unadjusted logistic regression models. However, independently, logistic regression revealed that glucose was associated with the moderate CRF group. Findings suggest that a lower CRF is associated with an unhealthy biochemical profile in non-physically active and overweight/obese individuals with HTN. As such, this population should look to increase physical activity in order to improve their CRF and biochemical profile. SN 0036-5513 YR 2018 FD 2018-11-17 LK https://hdl.handle.net/11556/4154 UL https://hdl.handle.net/11556/4154 LA eng NO Corres , P , Maldonado-Martín , S , Gorostegi-Anduaga , I , Fryer , S M , Jurio-Iriarte , B , MartínezAguirre-Betolaza , A , Arratibel-Imaz , I , Francisco-Terreros , S & Pérez-Asenjo , J 2018 , ' Is cardiorespiratory fitness independently associated with the biochemical profile in overweight/obese adults with primary hypertension? The EXERDIET-HTA study ' , Scandinavian Journal of Clinical and Laboratory Investigation , vol. 78 , no. 7-8 , pp. 613-620 . https://doi.org/10.1080/00365513.2018.1531297 NO Publisher Copyright: © 2018, © 2018 Medisinsk Fysiologisk Forenings Forlag (MFFF). NO This study was supported by the University of the Basque Country (EHU14/08). PC, IGA and AMAB were supported by the Basque Government with predoctoral grants. This study was supported by the University of the Basque Country (EHU14/08). PC, IGA and AMAB were supported by the Basque Government with predoctoral grants. Our special thanks to G. Rodrigo Aispuru for his medical assessment. Also thanks to the Department of Physical Education and Sport and Faculty of Education and Sport (University of the Basque Country, UPV/EHU) for believing in our project and providing the material and facilities at the outset. DS TECNALIA Publications RD 26 jul 2024