RT Journal Article
T1 Brain oscillatory activity as a biomarker of motor recovery in chronic stroke
A1 Ray, Andreas M.
A1 Figueiredo, Thiago D. C.
A1 López‐Larraz, Eduardo
A1 Birbaumer, Niels
A1 Ramos‐Murguialday, Ander
A1 López-Larraz, Eduardo
A1 Ramos-Murguialday, Ander
AB In the present work, we investigated the relationship of oscillatory sensorimotor brain activity to motor recovery. The neurophysiological data of 30 chronic stroke patients with severe upper‐limb paralysis are the basis of the observational study presented here. These patients underwent an intervention including movement training based on combined brain–machine interfaces and physiotherapy of several weeks recorded in a double‐blinded randomized clinical trial. We analyzed the alpha oscillations over the motor cortex of 22 of these patients employing multilevel linear predictive modeling. We identified a significant correlation between the evolution of the alpha desynchronization during rehabilitative intervention and clinical improvement. Moreover, we observed that the initial alpha desynchronization conditions its modulation during intervention: Patients showing a strong alpha desynchronization at the beginning of the training improved if they increased their alpha desynchronization. Patients showing a small alpha desynchronization at initial training stages improved if they decreased it further on both hemispheres. In all patients, a progressive shift of desynchronization toward the ipsilesional hemisphere correlates significantly with clinical improvement regardless of lesion location. The results indicate that initial alpha desynchronization might be key for stratification of patients undergoing BMI interventions and that its interhemispheric balance plays an important role in motor recovery.
SN 1065-9471
YR 2020
FD 2020-04-01
LA eng
NO Ray , A M , Figueiredo , T D C , López‐Larraz , E , Birbaumer , N , Ramos‐Murguialday , A , López-Larraz , E & Ramos-Murguialday , A 2020 , ' Brain oscillatory activity as a biomarker of motor recovery in chronic stroke ' , Human Brain Mapping , vol. 41 , no. 5 , pp. 1296-1308 . https://doi.org/10.1002/hbm.24876
NO Publisher Copyright: © 2019 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc.
DS TECNALIA Publications
RD 25 jul 2024