RT Journal Article
T1 Circulating miRNAs as Biomarkers of Obesity and Obesity-Associated Comorbidities in Children and Adolescents: A Systematic Review: 												A systematic review
A1 Oses, Maddi
A1 Margareto Sanchez, Javier
A1 Portillo, Maria P.
A1 Aguilera, Concepción María
A1 Labayen, Idoia
AB Early detection of obesity and its associated comorbidities in children needs priority for the development of effective therapeutic intervention. Circulating miRNAs (microRNAs) have been proposed as biomarkers for obesity and its comorbidities; therefore, we conducted a systematic review to summarize results of studies that have quantified the profile of miRNAs in children and adolescents with obesity and/or associated disorders. Nine studies aiming to examine differences in miRNA expression levels between children with normal weight and obesity or between obese children with or without cardiometabolic diseases were included in this review. We identified four miRNAs overexpressed in obesity (miR-222, miR-142–3, miR-140-5p, and miR-143) and two miRNAs (miR-122 and miR-34a) overexpressed in children with obesity and nonalcoholic fatty liver disease (NAFLD) and/or insulin resistance. In conclusion, circulating miRNAs are promising diagnostic biomarkers of obesity-associated diseases such as NAFLD and type 2 diabetes already in childhood. However, more studies in children, using massive search technology and with larger sample sizes, are required to draw any firm conclusions.
SN 2072-6643
YR 2019
FD 2019-12
LA eng
NO Oses , M , Margareto Sanchez , J , Portillo , M P , Aguilera , C M & Labayen , I 2019 , ' Circulating miRNAs as Biomarkers of Obesity and Obesity-Associated Comorbidities in Children and Adolescents: A Systematic Review : A systematic review ' , Nutrients , vol. 11 , no. 12 , 2890 , pp. 2890 . https://doi.org/10.3390/nu11122890
NO Publisher Copyright: © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
DS TECNALIA Publications
RD 22 jul 2024