RT Journal Article
T1 Biodegradable Bi-layered coating on polymeric orthopaedic implants for controlled release of drugs
A1 Argarate, Nerea
A1 Olalde, Beatriz
A1 Atorrasagasti, Garbiñe
A1 Valero, Jesus
A1 Carolina Cifuentes, Sandra
A1 Benavente, Rosario
A1 Lieblich, Marcela
A1 Luis González-Carrasco, José
AB A novel bone substitute incorporating biodegradable coatings on poly(d,l-lactide-co-lactide) (PLDL) implant has been developed. The polymer coatings were investigated as carrier of eugenol (EG) and dexamethasone (DM) which are suitable drugs to give antibacterial and anti-inflammatory function to the implant. The dip coating method was employed to coat the PLDL implant with poly(l-lactic acid) (PLLA) polymer. It has been observed that the thickness of the coating increased with the polymer concentration and the repetition of the dipping process showed an additive coating thickness compared to the single dipping. Moreover, it has been proved that a sequential drug release of EG and DM has been reached by incorporating the drugs onto each layer coating.
SN 0167-577X
YR 2014
FD 2014-10-01
LA eng
NO Argarate , N , Olalde , B , Atorrasagasti , G , Valero , J , Carolina Cifuentes , S , Benavente , R , Lieblich , M & Luis González-Carrasco , J 2014 , ' Biodegradable Bi-layered coating on polymeric orthopaedic implants for controlled release of drugs ' , Materials Letters , vol. 132 , pp. 193-195 . https://doi.org/10.1016/j.matlet.2014.06.070
NO The authors are thankful for financial support from MICINN , projects MAT2012-37736-C05-01 and -02, MAT2010-19883 and Spanish National Research Council- CSIC (Grant no. JAEPRE_2010_00285) and European Social Fund for Sandra Cifuentes ’ grant JAE-I3P .
DS TECNALIA Publications
RD 29 jul 2024