RT Journal Article
T1 Gene expression profiling of human gliomas reveals differences between GBM and LGA related to energy metabolism and notch signaling pathways
A1 Margareto, Javier
A1 Leis, Olatz
A1 Larrarte, Eider
A1 Idoate, Miguel A.
A1 Carrasco, Alejandro
A1 Lafuente, José Vicente
AB Human malignant astrocytic tumors are the most common primary brain malignancies. Human gliomas are classified according to the extent of anaplasia or 'de-differentiation' appearance. Although this type of histological classification is widely accepted, the extensive heterogeneity of astrocytic tumors has made their pathological classification rather difficult. New genome-scale high throughput technologies for gene expression profiling, such as DNA microarrays, are emerging as new tools to allow a more accurate identification and characterization of different tumor degrees by discovering new specific markers and pathways of each stage. Present work reports interesting results that might be useful to differentiate between tumor grades. Data presented here provides new evidences about the molecular basis underlying different tumor stages. In this sense, we identified key metabolic pathways, crucial for tumor progression, as being differentially regulated in different tumor stages. On the other hand, remarkable findings regarding Notch pathway are reported, as some members of this receptor family were found to be differentially expressed depending on the malignancy degree. Our results clearly point out important molecular differences between different tumor stages and suggest that more studies are needed to understand specific molecular events characteristic of each stage. These types of studies represent a first step to deepen into the tumor physiology, which may potentially help for better and a more precise diagnosis of gliomas.
SN 0895-8696
YR 2007
FD 2007-05
LK https://hdl.handle.net/11556/3758
UL https://hdl.handle.net/11556/3758
LA eng
NO Margareto , J , Leis , O , Larrarte , E , Idoate , M A , Carrasco , A & Lafuente , J V 2007 , ' Gene expression profiling of human gliomas reveals differences between GBM and LGA related to energy metabolism and notch signaling pathways ' , Journal of Molecular Neuroscience , vol. 32 , no. 1 , pp. 53-63 . https://doi.org/10.1007/s12031-007-0008-5
NO Acknowledgments This work was financially supported by grants 9/212.327-15887 (University of the Basque Country), SAIOTEK (Dpt. Industry. Government of the Basque Country) and by G03/114 Instituto de Salud Carlos III (Spanish Health Ministry).
DS TECNALIA Publications
RD 27 sept 2024