RT Journal Article
T1 Plasma polymerized silylated ciprofloxacin as an antibiotic coating
A1 Braceras, Inigo
A1 Azpiroz, Patxi
A1 Briz, Nerea
A1 Fratila, Raluca M.
A1 Oyarbide, Joseba
A1 Ipiñazar, Enrique
A1 Úlvarez, Noelia
A1 Atorrasagasti, Garbiñe
A1 Aizpurua, Jesus M.
AB Locally applied antibiotics under temporally controlled release present many advantages over systemic clinical treatments, e.g. efficiency and side effects. This can be achieved by a coating on top of the medical device, in which the antibiotic is stored. This study presents the use of plasma polymerization to produce such a coating using N,O-bis-tert- butyldimethylsilylated ciprofloxacin (silylciprofloxacin) as a precursor. Once exposed to physiological media, the outer layers of the coating release the antibiotic by a hydrolysis reaction. Thus, the plasma process parameters can control the speed of liberation through the coating polymerization. Besides, this study shows that the release products present antibiotic activity against a number of bacteria: E. coli, P. aeruginosa, and S. aureus. Ciprofloxacin release dynamics can be controlled by coating plasma polymerization parameters, allowing local controlled delivery of active antibiotic in physiologic conditions, and thus higher efficiency and lower side effects.
SN 1612-8850
YR 2011
FD 2011-07-22
LK https://hdl.handle.net/11556/2969
UL https://hdl.handle.net/11556/2969
LA eng
NO Braceras , I , Azpiroz , P , Briz , N , Fratila , R M , Oyarbide , J , Ipiñazar , E , Úlvarez , N , Atorrasagasti , G & Aizpurua , J M 2011 , ' Plasma polymerized silylated ciprofloxacin as an antibiotic coating ' , Plasma Processes and Polymers , vol. 8 , no. 7 , pp. 599-606 . https://doi.org/10.1002/ppap.201000160
DS TECNALIA Publications
RD 30 jul 2024