RT Journal Article
T1 DNA copy number variation and gene expression analyses reveal the implication of specific oncogenes and genes in GBM
A1 Margareto, Javier
A1 Leis, Olatz
A1 Larrarte, Eider
A1 Pomposo, Iñigo C.
A1 Garibi, Jesús María
A1 Lafuente, Jose Vicenté
AB To understand the pathogenesis of glioblastoma multiforme (GBM) we used high-resolution comparative genomic hybridization arrays and gene expression microarrays to identify DNA copy number alterations and gene expression changes in comparable sets of GBM samples. Gains were detected at chromosomes 1, 2, 7, 9, 12, 19, and 20 and losses at 6, 9, and 10. Gene expression analyses identified specific genes overexpressed in GBM mapping at amplified chromosomal regions. Among these genes we found genes involved in angiogenesis, extracellular matrix remodeling and several oncogenes. DNA copy number analysis along with gene expression profiles provides a powerful strategy to understand tumor progression and identification of genes involved in GBM pathogenesis.
SN 0735-7907
YR 2009
FD 2009-06
LK https://hdl.handle.net/11556/3839
UL https://hdl.handle.net/11556/3839
LA eng
NO Margareto , J , Leis , O , Larrarte , E , Pomposo , I C , Garibi , J M & Lafuente , J V 2009 , ' DNA copy number variation and gene expression analyses reveal the implication of specific oncogenes and genes in GBM ' , Cancer Investigation , vol. 27 , no. 5 , pp. 541-548 . https://doi.org/10.1080/07357900802563044
NO Olatz Leis is supported by the Health Department of the Basque Country Government. This work was financially supported by grants 9/212.327-15887 (University of the Basque Country), SAIOTEK (Dpt. Industry of the Basque Country); G03/114 Instituto de Salud Carlos III (Spanish Health Ministry) Fundación Mutua Madrileña and IT/460/07 (Basque Government).
DS TECNALIA Publications
RD 27 sept 2024