RT Journal Article
T1 Differences in Drug-Susceptibility Patterns between Mycobacterium avium, Mycobacterium intracellulare, and Mycobacterium chimaera Clinical Isolates: 												Prospective 8.5-Year Analysis by Three Laboratories
A1 Fernandez-Pittol, Mariana
A1 Batista-Arnau, Sara
A1 Román, Angely
A1 San Nicolás, Lorena
A1 Oliver, Laura
A1 González-Moreno, Olga
A1 Martínez, José Antonio
A1 Amaro-Rodríguez, Rosanel
A1 Soler, Néstor
A1 Gené, Amadeu
A1 González-Cuevas, Araceli
A1 Tudó, Griselda
A1 Gonzalez-Martin, Julian
AB Background: It has been suggested that Mycobacterium avium, Mycobacterium intracellulare, and M. chimaera have differential drug susceptibility patterns. We prospectively analyzed and compared the drug susceptibility patterns among these species over an 8.5-year period. Methods: A microdilution method (Slomyco®) was performed for drug susceptibility testing of 402 M. avium, 273 M. intracellulare, and 139 M. chimaera clinical isolates. Results: M. avium showed significantly higher resistance to moxifloxacin, ciprofloxacin, rifampicin, ethambutol, streptomycin, linezolid, cotrimoxazole, and clarithromycin. M. avium also showed higher minimum inhibitory concentrations (MIC) than M. intracellulare and M. chimaera against all drugs except ethionamide, to which M. intracellulare and M. chimaera showed greater resistance. Conclusions: Our series demonstrated differential drug resistance patterns among the most frequent M. avium complex species. M. avium was more resistant than M. intracellulare and M. chimaera versus eight antibiotics and showed greater MIC values to most of the antibiotics studied. These data suggest that knowledge of the local distribution and susceptibility profiles of these pathogens is essential for adequate clinical management.
SN 2079-6382
YR 2023
FD 2023-01
LK https://hdl.handle.net/11556/5315
UL https://hdl.handle.net/11556/5315
LA eng
NO Fernandez-Pittol , M , Batista-Arnau , S , Román , A , San Nicolás , L , Oliver , L , González-Moreno , O , Martínez , J A , Amaro-Rodríguez , R , Soler , N , Gené , A , González-Cuevas , A , Tudó , G & Gonzalez-Martin , J 2023 , ' Differences in Drug-Susceptibility Patterns between Mycobacterium avium, Mycobacterium intracellulare, and Mycobacterium chimaera Clinical Isolates : Prospective 8.5-Year Analysis by Three Laboratories ' , Antibiotics , vol. 12 , no. 1 , 64 . https://doi.org/10.3390/antibiotics12010064
NO Publisher Copyright: © 2022 by the authors.
NO We acknowledge support from the Spanish Ministry of Science and Innovation and State Research Agency through the “Centro de Excelencia Severo Ochoa 2019–2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program”. This study was supported by the Ministerio de Economía y Competitividad, Instituto de Salud Carlos III, financed by the European Regional Development Fund (ERDF, FEDER) “A Way to Achieve Europe”, the Spanish Ministry of Health (grant number FIS16/01047), Planes Nacionales de I+D+I 2008-2011/2013–2016, and Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Economía y Competitividad. This study was also supported by a grant (201816-10) from the Fundació La Marató de TV3, a grant (937-2019) from the Sociedad Española de Neumología y Cirugía Torácica (SEPAR), and by a grant (2017SGR0809) from the Departament d’Universitats, Recerca i Societat de la Informació de la Generalitat de Catalunya.
DS TECNALIA Publications
RD 29 sept 2024