RT Journal Article
T1 Computational and experimental model of transdermal iontophorethic drug delivery system
A1 Filipovic, Nenad
A1 Saveljic, Igor
A1 Rac, Vladislav
A1 Graells, Beatriz Olalde
A1 Bijelic, Goran
AB The concept of iontophoresis is often applied to increase the transdermal transport of drugs and other bioactive agents into the skin or other tissues. It is a non-invasive drug delivery method which involves electromigration and electroosmosis in addition to diffusion and is shown to be a viable alternative to conventional administration routs such as oral, hypodermic and intravenous injection. In this study we investigated, experimentally and numerically, in vitro drug delivery of dexamethasone sodium phosphate to porcine skin. Different current densities, delivery durations and drug loads were investigated experimentally and introduced as boundary conditions for numerical simulations. Nernst–Planck equation was used for calculation of active substance flux through equivalent model of homogeneous hydrogel and skin layers. The obtained numerical results were in good agreement with experimental observations. A comprehensive in-silico platform, which includes appropriate numerical tools for fitting, could contribute to iontophoretic drug-delivery devices design and correct dosage and drug clearance profiles as well as to perform much faster in-silico experiments to better determine parameters and performance criteria of iontophoretic drug delivery.
SN 0378-5173
YR 2017
FD 2017-11-30
LK https://hdl.handle.net/11556/4180
UL https://hdl.handle.net/11556/4180
LA eng
NO Filipovic , N , Saveljic , I , Rac , V , Graells , B O & Bijelic , G 2017 , ' Computational and experimental model of transdermal iontophorethic drug delivery system ' , International Journal of Pharmaceutics , vol. 533 , no. 2 , pp. 383-388 . https://doi.org/10.1016/j.ijpharm.2017.05.066
NO Publisher Copyright: © 2017 Elsevier B.V.
DS TECNALIA Publications
RD 26 jul 2024