RT Journal Article
T1 Fabrication of ultrahigh-molecular-weight polyethylene porous implant for bone application
A1 Olalde, Beatriz
A1 Ayerdi-Izquierdo, Ana
A1 Fernández, Rubén
A1 García-Urkia, Nerea
A1 Atorrasagasti, Garbiñe
A1 Bijelic, Goran
AB Porous implants play a crucial role in allowing ingrowth of host connective tissue and thereby help in keeping the implant in its place. With the aim of mimicking the microstructure of natural extracellular matrix, ultrahigh-molecular-weight polyethylene (UHMWPE) porous samples with a desirable pore size distribution were developed by combining thermally induced phase separation and salt leaching techniques. The porous UHMWPE samples consisted of a nanofibrous UHMWPE matrix with a fibre diameter smaller than 500 nm, highly interconnected, with a controllable pore diameter from nanoscale to 300 μm. Moreover, a porous UHMWPE sample was also developed as a continuous and homogeneous coating onto the UHMWPE dense sample. The dense/porous UHMWPE sample supported human foetal osteoblast 1.19 cell line proliferation and differentiation, indicating the potential of porous UHMWPE with a desirable pore size distribution for bone application. An osseointegration model in the sheep revealed substantial bone formation within the pore layer at 12 weeks via SEM evaluation. Ingrown bone was more closely opposed to the pore wall when compared to the dense UHMWPE control. These results indicate that dense/porous UHMWPE could provide improved osseointegration while maintaining the structural integrity necessary for load-bearing orthopaedic application.
SN 0334-6447
YR 2020
FD 2020-09-01
LK https://hdl.handle.net/11556/4467
UL https://hdl.handle.net/11556/4467
LA eng
NO Olalde , B , Ayerdi-Izquierdo , A , Fernández , R , García-Urkia , N , Atorrasagasti , G & Bijelic , G 2020 , ' Fabrication of ultrahigh-molecular-weight polyethylene porous implant for bone application ' , Journal of Polymer Engineering , vol. 40 , no. 8 , pp. 685-692 . https://doi.org/10.1515/polyeng-2019-0386
NO Publisher Copyright: © 2020 Walter de Gruyter GmbH, Berlin/Boston 2020.
NO EMAITEK program: Basque Government. Basque Government. Department of Technology, Innovation and Competitiveness.
DS TECNALIA Publications
RD 26 jul 2024