TY  - Journal Article
AU  - Mendibil, Unai
AU  - Ruiz-Hernandez, Raquel
AU  - Retegi-Carrion, Sugoi
AU  - Garcia-Urquia, Nerea
AU  - Olalde-Graells, Beatriz
AU  - Abarrategi, Ander
TI  - Tissue-Specific Decellularization Methods: Rationale and Strategies to Achieve Regenerative Compounds
PY  - 2020
PB  - Multidisciplinary Digital Publishing Institute (MDPI)
AB  - The extracellular matrix (ECM) is a complex network with multiple functions, including
specific functions during tissue regeneration. Precisely, the properties of the ECM have been
thoroughly used in tissue engineering and regenerative medicine research, aiming to restore the
function of damaged or dysfunctional tissues. Tissue decellularization is gaining momentum as
a technique to obtain potentially implantable decellularized extracellular matrix (dECM) with
well-preserved key components. Interestingly, the tissue-specific dECM is becoming a feasible option
to carry out regenerative medicine research, with multiple advantages compared to other approaches.
This review provides an overview of the most common methods used to obtain the dECM and
summarizes the strategies adopted to decellularize specific tissues, aiming to provide a helpful guide
for future research development.
SN  - 1661-6596
UR  - http://hdl.handle.net/11556/974
DX  - 10.3390/ijms21155447
ER  -