Ion implantation induced nanotopography on titanium and bone cell adhesion

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dc.contributor.authorBraceras, Iñigo
dc.contributor.authorVera, Carolina
dc.contributor.authorAyerdi-Izquierdo, Ana
dc.contributor.authorMuñoz, Roberto
dc.contributor.authorLorenzo, Jaione
dc.contributor.authorAlvarez, Noelia
dc.contributor.authorDe Maeztu, Miguel Ángel
dc.contributor.institutionINGENIERÍA DE SUPERFICIES
dc.contributor.institutionBiomateriales
dc.date.accessioned2024-07-24T12:06:27Z
dc.date.available2024-07-24T12:06:27Z
dc.date.issued2014-08-15
dc.description.abstractPermanent endo-osseous implants require a fast, reliable and consistent osseointegration, i.e. intimate bonding between bone and implant, so biomechanical loads can be safely transferred. Among the parameters that affect this process, it is widely admitted that implant surface topography, surface energy and composition play an important role. Most surface treatments to improve osseointegration focus on micro-scale features, as few can effectively control the effects of the treatment at nanoscale. On the other hand, ion implantation allows controlling such nanofeatures. This study has investigated the nanotopography of titanium, as induced by different ion implantation surface treatments, its similarity with human bone tissue structure and its effect on human bone cell adhesion, as a first step in the process of osseointegration. The effect of ion implantation treatment parameters such as energy (40-80 keV), fluence (1-2 e17 ion/cm 2 ) and ion species (Kr, Ar, Ne and Xe) on the nanotopography of medical grade titanium has been measured and assessed by AFM and contact angle. Then, in vitro tests have been performed to assess the effect of these nanotopographies on osteoblast adhesion. The results have shown that the nanostructure of bone and the studied ion implanted surfaces, without surface chemistry modification, are in the same range and that such modifications, in certain conditions, do have a statistically significant effect on bone tissue forming cell adhesion.en
dc.description.sponsorshipThe work was financially supported by the ETORTEK BIOSUPERFICIES , Basque Government IE07-201 research programme and the NACRE project of the Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN) .
dc.description.statusPeer reviewed
dc.format.extent7
dc.identifier.citationBraceras , I , Vera , C , Ayerdi-Izquierdo , A , Muñoz , R , Lorenzo , J , Alvarez , N & De Maeztu , M Á 2014 , ' Ion implantation induced nanotopography on titanium and bone cell adhesion ' , Applied Surface Science , vol. 310 , pp. 24-30 . https://doi.org/10.1016/j.apsusc.2014.03.118
dc.identifier.doi10.1016/j.apsusc.2014.03.118
dc.identifier.issn0169-4332
dc.identifier.urihttps://hdl.handle.net/11556/3664
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=84903269919&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofApplied Surface Science
dc.relation.projectIDEusko Jaurlaritza, IE07-201
dc.relation.projectIDCentro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina, CIBER-BBN
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subject.keywordsBone
dc.subject.keywordsCell adhesion
dc.subject.keywordsHydrophilicity
dc.subject.keywordsIon implantation
dc.subject.keywordsNanotopography
dc.subject.keywordsOsseointegration
dc.subject.keywordsGeneral Chemistry
dc.subject.keywordsCondensed Matter Physics
dc.subject.keywordsGeneral Physics and Astronomy
dc.subject.keywordsSurfaces and Interfaces
dc.subject.keywordsSurfaces, Coatings and Films
dc.titleIon implantation induced nanotopography on titanium and bone cell adhesionen
dc.typejournal article
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