Bilateral activations in operculo-insular area show temporal dissociation after peripheral electrical stimulation in healthy adults

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dc.contributor.authorHautasaari, Pekka
dc.contributor.authorSaloranta, Harri
dc.contributor.authorSavić, Andrej M.
dc.contributor.authorKorniloff, Katariina
dc.contributor.authorKujala, Urho M.
dc.contributor.authorTarkka, Ina M.
dc.contributor.institutionTecnalia Research & Innovation
dc.date.accessioned2024-08-20T14:05:01Z
dc.date.available2024-08-20T14:05:01Z
dc.date.issued2020-12
dc.descriptionPublisher Copyright: © 2018 Federation of European Neuroscience Societies and John Wiley & Sons Ltd
dc.description.abstractInterhemispheric transfer is necessary for sensory integration and coordination of body sides. We studied how somatosensory input from one body side may reach both body sides. First, we investigated with 17 healthy adults in which uni- and bilateral brain areas were involved in consecutive stages of automatic sensory processing of non-nociceptive peripheral stimulation. Somatosensory evoked fields (SEFs) to electrical stimulation were recorded with 306-channel magnetoencephalography in two conditions. First, SEFs were registered following sensory radial nerve (RN) stimulation to dorsal surface of the right hand and second, following median nerve (MN) stimulation at the right wrist. Cortical activations were located in contralateral postcentral gyrus after MN and RN stimulations and in bilateral operculo-insular area after RN stimulation. First component occurred earlier after MN than RN stimulation. Middle latency components had similar latencies with stronger activation in contralateral postcentral gyrus after MN than RN stimulation. Interestingly, long latency components located in bilateral operculo-insular area after RN stimulation showed latency difference between hemispheres, i.e. activation peaked earlier in contralateral than in ipsilateral side. Additional experiments comparing novel intracutaneous nociceptive, RN and MN electrical stimuli confirmed bilateral long latency activation elicited by each stimulus type and highlighted latency differences between hemispheres. Variations in activation of bilateral operculo-insular areas may corroborate their role in pain network and in multisensory integration. Our findings imply that these areas present a relay station in multisensory stimulus detection.en
dc.description.statusPeer reviewed
dc.format.extent9
dc.identifier.citationHautasaari , P , Saloranta , H , Savić , A M , Korniloff , K , Kujala , U M & Tarkka , I M 2020 , ' Bilateral activations in operculo-insular area show temporal dissociation after peripheral electrical stimulation in healthy adults ' , European Journal of Neuroscience , vol. 52 , no. 12 , pp. 4604-4612 . https://doi.org/10.1111/ejn.13946
dc.identifier.doi10.1111/ejn.13946
dc.identifier.issn0953-816X
dc.identifier.urihttps://hdl.handle.net/11556/4774
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85050457964&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofEuropean Journal of Neuroscience
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject.keywordsmagnetoencephalography
dc.subject.keywordsmedian nerve
dc.subject.keywordsnociception
dc.subject.keywordsradial nerve
dc.subject.keywordssensory cortex
dc.subject.keywordsGeneral Neuroscience
dc.titleBilateral activations in operculo-insular area show temporal dissociation after peripheral electrical stimulation in healthy adultsen
dc.typejournal article
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