Non-invasive brain-spine interface: Continuous control of trans-spinal magnetic stimulation using EEG

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dc.contributor.authorInsausti-Delgado, Ainhoa
dc.contributor.authorLópez-Larraz, Eduardo
dc.contributor.authorNishimura, Yukio
dc.contributor.authorZiemann, Ulf
dc.contributor.authorRamos-Murguialday, Ander
dc.contributor.institutionMedical Technologies
dc.date.issued2022-10-31
dc.descriptionPublisher Copyright: Copyright © 2022 Insausti-Delgado, López-Larraz, Nishimura, Ziemann and Ramos-Murguialday.
dc.description.abstractBrain-controlled neuromodulation has emerged as a promising tool to promote functional recovery in patients with motor disorders. Brain-machine interfaces exploit this neuromodulatory strategy and could be used for restoring voluntary control of lower limbs. In this work, we propose a non-invasive brain-spine interface (BSI) that processes electroencephalographic (EEG) activity to volitionally control trans-spinal magnetic stimulation (ts-MS), as an approach for lower-limb neurorehabilitation. This novel platform allows to contingently connect motor cortical activation during leg motor imagery with the activation of leg muscles via ts-MS. We tested this closed-loop system in 10 healthy participants using different stimulation conditions. This BSI efficiently removed stimulation artifacts from EEG regardless of ts-MS intensity used, allowing continuous monitoring of cortical activity and real-time closed-loop control of ts-MS. Our BSI induced afferent and efferent evoked responses, being this activation ts-MS intensity-dependent. We demonstrated the feasibility, safety and usability of this non-invasive BSI. The presented system represents a novel non-invasive means of brain-controlled neuromodulation and opens the door towards its integration as a therapeutic tool for lower-limb rehabilitation.en
dc.description.sponsorshipThis study was funded by the Eureka-Eurostars program (SubliminalHomeRehab (E! 113928)), the Fortüne-Program of the University of Tübingen (2422-0-1 and 2556-0-0 to ELL), the Junior Research Group program inside the Fortüne-Funding of the University of Tübingen (2452-0-0 to ARM), and the ELKARTEK funding program of the Basque Government (BIOSTIM KK-2021/0096). AID was funded by the Basque Government’s scholarship for predoctoral students.
dc.description.statusPeer reviewed
dc.identifier.citationInsausti-Delgado , A , López-Larraz , E , Nishimura , Y , Ziemann , U & Ramos-Murguialday , A 2022 , ' Non-invasive brain-spine interface : Continuous control of trans-spinal magnetic stimulation using EEG ' , Frontiers in Bioengineering and Biotechnology , vol. 10 , 975037 . https://doi.org/10.3389/fbioe.2022.975037
dc.identifier.doi10.3389/fbioe.2022.975037
dc.identifier.issn2296-4185
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85141935682&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofFrontiers in Bioengineering and Biotechnology
dc.relation.projectIDEberhard Karls Universität Tübingen, 2556-0-0-2452-0-0-2422-0-1
dc.relation.projectIDEusko Jaurlaritza, BIOSTIM KK-2021/0096
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject.keywordsEEG
dc.subject.keywordsartifact removal
dc.subject.keywordsbrain-spine interface
dc.subject.keywordsneuromodulation
dc.subject.keywordstrans-spinal magnetic stimulation
dc.subject.keywordsBiotechnology
dc.subject.keywordsBioengineering
dc.subject.keywordsHistology
dc.subject.keywordsBiomedical Engineering
dc.titleNon-invasive brain-spine interface: Continuous control of trans-spinal magnetic stimulation using EEGen
dc.typejournal article
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