Intensity and Dose of Neuromuscular Electrical Stimulation Influence Sensorimotor Cortical Excitability

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dc.contributor.authorInsausti-Delgado, Ainhoa
dc.contributor.authorLópez-Larraz, Eduardo
dc.contributor.authorOmedes, Jason
dc.contributor.authorRamos-Murguialday, Ander
dc.contributor.institutionTecnalia Research & Innovation
dc.contributor.institutionMedical Technologies
dc.date.issued2021-01-15
dc.descriptionPublisher Copyright: © Copyright © 2021 Insausti-Delgado, López-Larraz, Omedes and Ramos-Murguialday.
dc.description.abstractNeuromuscular electrical stimulation (NMES) of the nervous system has been extensively used in neurorehabilitation due to its capacity to engage the muscle fibers, improving muscle tone, and the neural pathways, sending afferent volleys toward the brain. Although different neuroimaging tools suggested the capability of NMES to regulate the excitability of sensorimotor cortex and corticospinal circuits, how the intensity and dose of NMES can neuromodulate the brain oscillatory activity measured with electroencephalography (EEG) is still unknown to date. We quantified the effect of NMES parameters on brain oscillatory activity of 12 healthy participants who underwent stimulation of wrist extensors during rest. Three different NMES intensities were included, two below and one above the individual motor threshold, fixing the stimulation frequency to 35 Hz and the pulse width to 300 μs. Firstly, we efficiently removed stimulation artifacts from the EEG recordings. Secondly, we analyzed the effect of amplitude and dose on the sensorimotor oscillatory activity. On the one hand, we observed a significant NMES intensity-dependent modulation of brain activity, demonstrating the direct effect of afferent receptor recruitment. On the other hand, we described a significant NMES intensity-dependent dose-effect on sensorimotor activity modulation over time, with below-motor-threshold intensities causing cortical inhibition and above-motor-threshold intensities causing cortical facilitation. Our results highlight the relevance of intensity and dose of NMES, and show that these parameters can influence the recruitment of the sensorimotor pathways from the muscle to the brain, which should be carefully considered for the design of novel neuromodulation interventions based on NMES.en
dc.description.statusPeer reviewed
dc.format.extent2490266
dc.identifier.citationInsausti-Delgado , A , López-Larraz , E , Omedes , J & Ramos-Murguialday , A 2021 , ' Intensity and Dose of Neuromuscular Electrical Stimulation Influence Sensorimotor Cortical Excitability ' , Frontiers in Neuroscience , vol. 14 , 593360 . https://doi.org/10.3389/fnins.2020.593360
dc.identifier.doi10.3389/fnins.2020.593360
dc.identifier.issn1662-4548
dc.identifier.otherresearchoutputwizard: 11556/1076
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85100231273&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofFrontiers in Neuroscience
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject.keywordsAfferent cortical activation
dc.subject.keywordsArtifact removal
dc.subject.keywordsElectroencephalography (EEG)
dc.subject.keywordsNeuromuscular electrical stimulation (NMES)
dc.subject.keywordsSensorimotor oscillatory rhythm
dc.subject.keywordsAfferent cortical activation
dc.subject.keywordsArtifact removal
dc.subject.keywordsElectroencephalography (EEG)
dc.subject.keywordsNeuromuscular electrical stimulation (NMES)
dc.subject.keywordsSensorimotor oscillatory rhythm
dc.subject.keywordsGeneral Neuroscience
dc.subject.keywordsFunding Info
dc.subject.keywordsThis study was funded by the Bundesministerium für Bildung und Forschung BMBF MOTORBIC (FKZ 13GW0053), AMORSA (FKZ 16SV7754), and the Fortüne-Program of the University of Tübingen (2422-0-1 and 2556-0-0
dc.subject.keywordsThis study was funded by the Bundesministerium für Bildung und Forschung BMBF MOTORBIC (FKZ 13GW0053), AMORSA (FKZ 16SV7754), and the Fortüne-Program of the University of Tübingen (2422-0-1 and 2556-0-0
dc.titleIntensity and Dose of Neuromuscular Electrical Stimulation Influence Sensorimotor Cortical Excitabilityen
dc.typejournal article
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