Effect of nanotubes and apatite on growth factor release from PLLA scaffolds

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dc.contributor.authorZande, Meike van der
dc.contributor.authorWalboomers, X. Frank
dc.contributor.authorOlalde, Beatriz
dc.contributor.authorJurado, Maria J.
dc.contributor.authorÁlava, J. Iñaki
dc.contributor.authorBoerman, Otto C.
dc.contributor.authorJansen, John A.
dc.contributor.institutionBiomateriales
dc.contributor.institutionTecnalia Research & Innovation
dc.date.accessioned2024-07-24T12:11:02Z
dc.date.available2024-07-24T12:11:02Z
dc.date.issued2011-06
dc.description.abstractThere is an evident clinical need for artificial bone restorative materials. In this respect, novel composites based on poly(L-lactic acid) (PLLA) have been described. The bone response of such polymer-based composites is usually improved by the addition of bone morphogenetic protein-2 (BMP-2). However, released BMP-2 is cleared almost immediately from the site of implantation by diffusion, whereas a prolonged retention of BMP-2 onto the scaffold has been suggested to be more favourable. Besides the ability to improve the mechanical strength and osteoconductivity of polymeric scaffolds, both carbon nanotubes (CNTs) and microhydroxyapatite (μHA) have been described to facilitate such retention of BMP-2 when incorporated into a composite scaffold. Therefore, in the current study, radiolabelled BMP-2 was loaded onto plain PLLA and composite PLLA-CNT-μHA scaffolds. Subsequently, the scaffolds were implanted subcutaneously for 5 weeks in rats and BMP-2 release was measured. Release started with an initial phase of quick release, followed by a gradual release of BMP-2. Both scaffold types comprised the same in vivo release properties for BMP-2. The bioactivity of the BMP-2 remained unaltered. It can be concluded that incorporated CNTs and μHA did not affect BMP-2 release from composite scaffold materials.en
dc.description.statusPeer reviewed
dc.format.extent7
dc.identifier.citationZande , M V D , Walboomers , X F , Olalde , B , Jurado , M J , Álava , J I , Boerman , O C & Jansen , J A 2011 , ' Effect of nanotubes and apatite on growth factor release from PLLA scaffolds ' , Journal of Tissue Engineering and Regenerative Medicine , vol. 5 , no. 6 , pp. 476-482 . https://doi.org/10.1002/term.339
dc.identifier.doi10.1002/term.339
dc.identifier.issn1932-6254
dc.identifier.urihttps://hdl.handle.net/11556/4140
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=79956282203&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofJournal of Tissue Engineering and Regenerative Medicine
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject.keywordsBMP (bone morphogenetic protein)
dc.subject.keywordsBone graft
dc.subject.keywordsCarbon nanotubes
dc.subject.keywordsComposite
dc.subject.keywordsDrug release
dc.subject.keywordsHydroxyapatite
dc.subject.keywordsIn vivo
dc.subject.keywordsPLLA (poly-L-lactic acid)
dc.subject.keywordsMedicine (miscellaneous)
dc.subject.keywordsBiomaterials
dc.subject.keywordsBiomedical Engineering
dc.titleEffect of nanotubes and apatite on growth factor release from PLLA scaffoldsen
dc.typejournal article
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