Modeling neural differentiation on micropatterned substrates coated with neural matrix components

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dc.contributor.authorGarcía-Parra, Patricia
dc.contributor.authorCavaliere, Fabio
dc.contributor.authorMaroto, Marcos
dc.contributor.authorBilbao, Leire
dc.contributor.authorObieta, Isabel
dc.contributor.authorde Munain, Adolfo López
dc.contributor.authorÁlava, José Iñaki
dc.contributor.authorIzeta, Ander
dc.contributor.institutionPRINTEX
dc.contributor.institutionTecnalia Research & Innovation
dc.date.accessioned2024-07-24T12:00:45Z
dc.date.available2024-07-24T12:00:45Z
dc.date.issued2012-03-14
dc.description.abstractTopographical and biochemical characteristics of the substrate are critical for neuronal differentiation including axonal outgrowth and regeneration of neural circuits in vivo. Contact stimuli and signaling molecules allow neurons to develop and stabilize synaptic contacts. Here we present the development, characterization and functional validation of a new polymeric support able to induce neuronal differentiation in both PC12 cell line and adult primary skin-derived precursor cells (SKPs) in vitro. By combining a photolithographic technique with use of neural extracellular matrix (ECM) as a substrate, a biocompatible and efficient microenvironment for neuronal differentiation was developed.en
dc.description.statusPeer reviewed
dc.identifier.citationGarcía-Parra , P , Cavaliere , F , Maroto , M , Bilbao , L , Obieta , I , de Munain , A L , Álava , J I & Izeta , A 2012 , ' Modeling neural differentiation on micropatterned substrates coated with neural matrix components ' , Frontiers in Cellular Neuroscience , no. MARCH , 10 . https://doi.org/10.3389/fncel.2012.00010
dc.identifier.doi10.3389/fncel.2012.00010
dc.identifier.issn1662-5102
dc.identifier.urihttps://hdl.handle.net/11556/3072
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=84859372162&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofFrontiers in Cellular Neuroscience
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject.keywordsECM (extracellular matrix)
dc.subject.keywordsMicropatterning
dc.subject.keywordsNerve tissue engineering
dc.subject.keywordsNeural differentiation
dc.subject.keywordsPhotolithography
dc.subject.keywordsProgenitor cell
dc.subject.keywordsCellular and Molecular Neuroscience
dc.titleModeling neural differentiation on micropatterned substrates coated with neural matrix componentsen
dc.typejournal article
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