Neurogenetic profiles delineate large-scale connectivity dynamics of the human brain

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dc.contributor.authorDiez, Ibai
dc.contributor.authorSepulcre, Jorge
dc.contributor.institutionTecnalia Research & Innovation
dc.date.issued2018-12-01
dc.descriptionPublisher Copyright: © 2018, The Author(s).
dc.description.abstractExperimental and modeling work of neural activity has described recurrent and attractor dynamic patterns in cerebral microcircuits. However, it is still poorly understood whether similar dynamic principles exist or can be generalizable to the large-scale level. Here, we applied dynamic graph theory-based analyses to evaluate the dynamic streams of whole-brain functional connectivity over time across cognitive states. Dynamic connectivity in local networks is located in attentional areas during tasks and primary sensory areas during rest states, and dynamic connectivity in distributed networks converges in the default mode network (DMN) in both task and rest states. Importantly, we find that distinctive dynamic connectivity patterns are spatially associated with Allen Human Brain Atlas genetic transcription levels of synaptic long-term potentiation and long-term depression-related genes. Our findings support the neurobiological basis of large-scale attractor-like dynamics in the heteromodal cortex within the DMN, irrespective of cognitive state.en
dc.description.statusPeer reviewed
dc.format.extent2296926
dc.identifier.citationDiez , I & Sepulcre , J 2018 , ' Neurogenetic profiles delineate large-scale connectivity dynamics of the human brain ' , Nature Communications , vol. 9 , no. 1 , 3876 . https://doi.org/10.1038/s41467-018-06346-3
dc.identifier.doi10.1038/s41467-018-06346-3
dc.identifier.issn2041-1723
dc.identifier.otherresearchoutputwizard: 11556/623
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85053808773&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofNature Communications
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject.keywordsBrain
dc.subject.keywordsCognition
dc.subject.keywordsConnectivity
dc.subject.keywordsExperimental study
dc.subject.keywordsGene
dc.subject.keywordsGenetic analysis
dc.subject.keywordsModeling
dc.subject.keywordsSensory system
dc.subject.keywordsBrain
dc.subject.keywordsCognition
dc.subject.keywordsConnectivity
dc.subject.keywordsExperimental study
dc.subject.keywordsGene
dc.subject.keywordsGenetic analysis
dc.subject.keywordsModeling
dc.subject.keywordsSensory system
dc.subject.keywordsGeneral Chemistry
dc.subject.keywordsGeneral Biochemistry,Genetics and Molecular Biology
dc.subject.keywordsGeneral Physics and Astronomy
dc.subject.keywordsFunding Info
dc.subject.keywordsThis work has been partially supported by the National Institutes of Health (NIH) grant_x000D_ K23EB019023 (to J.S.), Postdoctoral Fellowship Program from the Basque Country_x000D_ Government and Bizkaia Talent (to I.D.).
dc.subject.keywordsThis work has been partially supported by the National Institutes of Health (NIH) grant_x000D_ K23EB019023 (to J.S.), Postdoctoral Fellowship Program from the Basque Country_x000D_ Government and Bizkaia Talent (to I.D.).
dc.titleNeurogenetic profiles delineate large-scale connectivity dynamics of the human brainen
dc.typejournal article
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