Safe-by-design strategies applied to scaffold hybrid manufacturing

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dc.contributor.authorLópez De Ipiña, Jesús M.
dc.contributor.authorVaquero, Celina
dc.contributor.authorEgizabal, Ainhoa
dc.contributor.authorPatelli, Alessandro
dc.contributor.authorMoroni, Lorenzo
dc.contributor.institutionSMART_MON
dc.contributor.institutionPRINTEX
dc.contributor.institutionBiomateriales
dc.date.issued2021-06-22
dc.descriptionPublisher Copyright: © Published under licence by IOP Publishing Ltd.
dc.description.abstractThe EU-project FAST (GA 685825) has developed a 3D printer machine prototype for the manufacture of bone implants (scaffolds), by merging masterbatches of biodegradable polymer poly(ethylene oxide)terephthalate/poly(butylene terephthalate) [PEOT/PBT] doped with nanofillers [reduced graphene oxide (rGO), hydroxyapatite (HA) and magnesium aluminium hydroxide ciprofloxacin hydrotalcite (LDH-CFX)], and atmospheric plasma technology. This paper focus on the safe design strategies identified by FAST to address the risk to health resulting from the potential airborne emission of nano-objects and their aggregates and agglomerates (NOAAs) by the 3D printer prototype, which might result in occupational exposures by inhalation. The work also includes measurements of airborne emissions and occupational exposures carried out during the verification stage of the prototype design. Nanofillers particles (rGO, n-HA, LDH-CFX) were not observed, neither at source nor in the working area, suggesting no release of free nanofillers to the air one they have been embedded in the polymer masterbatch. Additionally, the exposure in the workplace was far below the selected Occupational Exposure Levels (OELs), for total particle number concentration (PNC), dust, elemental carbon (EC) and volatile organic compounds (VOCs). The results showed that, when working with the current prototype in normal operation (for its intended use) and with controls enabled [enclosure with the doors closed and Local Exhaust Ventilation (LEV) activated], the emission from the machine and the worker's exposure to NOAAs are well controlled.en
dc.description.statusPeer reviewed
dc.format.extent1
dc.format.extent880708
dc.identifier.citationLópez De Ipiña , J M , Vaquero , C , Egizabal , A , Patelli , A & Moroni , L 2021 , ' Safe-by-design strategies applied to scaffold hybrid manufacturing ' , Journal of Physics: Conference Series , vol. 1953 , no. 1 , 012009 , pp. 12009 . https://doi.org/10.1088/1742-6596/1953/1/012009
dc.identifier.doi10.1088/1742-6596/1953/1/012009
dc.identifier.issn1742-6588
dc.identifier.otherresearchoutputwizard: 11556/1167
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85109016726&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofJournal of Physics: Conference Series
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject.keywordsHealth risks
dc.subject.keywordsPrinting presses
dc.subject.keywordsSafety engineering
dc.subject.keywordsVolatile organic compounds
dc.subject.keywordsVentilation exhausts
dc.subject.keywords3D printers
dc.subject.keywordsHealth risks
dc.subject.keywordsPrinting presses
dc.subject.keywordsSafety engineering
dc.subject.keywordsVolatile organic compounds
dc.subject.keywordsVentilation exhausts
dc.subject.keywords3D printers
dc.subject.keywordsGeneral Physics and Astronomy
dc.subject.keywordsProject ID
dc.subject.keywordsinfo:eu-repo/grantAgreement/EC/H2020/685825/EU/Functionally graded Additive Manufacturing scaffolds by hybrid manufacturing/FAST
dc.subject.keywordsinfo:eu-repo/grantAgreement/EC/H2020/685825/EU/Functionally graded Additive Manufacturing scaffolds by hybrid manufacturing/FAST
dc.subject.keywordsFunding Info
dc.subject.keywordsThe project FAST received funding from the European Union’s Horizon 2020 research and innovation programme, under grant agreement Nº 685825. This paper reflects only the authors’ views, and the Commission is not responsible for any use that may be made of the information contained therein.
dc.subject.keywordsThe project FAST received funding from the European Union’s Horizon 2020 research and innovation programme, under grant agreement Nº 685825. This paper reflects only the authors’ views, and the Commission is not responsible for any use that may be made of the information contained therein.
dc.titleSafe-by-design strategies applied to scaffold hybrid manufacturingen
dc.typeconference output
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