Residual Upper Arm Motor Function Primes Innervation of Paretic Forearm Muscles in Chronic Stroke after Brain-Machine Interface (BMI) Training

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dc.contributor.authorCurado, Marco Rocha
dc.contributor.authorGarcia-Cossio, Eliana
dc.contributor.authorBroetz, Doris
dc.contributor.authorAgostini, Manuel
dc.contributor.authorCho, Woosang
dc.contributor.authorLima-Brasil, Fabricio
dc.contributor.authorYilmaz, Oezge
dc.contributor.authorLiberati, Giulia
dc.contributor.authorLepski, Guilherme
dc.contributor.authorBirbaumer, Niels
dc.contributor.authorRamos-Murguialday, Ander
dc.contributor.institutionTecnalia Research & Innovation
dc.contributor.institutionMedical Technologies
dc.date.issued2015-10-23
dc.descriptionPublisher Copyright: © 2015 Curado et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.description.abstractBackground Abnormal upper arm-forearm muscle synergies after stroke are poorly understood. We investigated whether upper arm function primes paralyzed forearm muscles in chronic stroke patients after Brain-Machine Interface (BMI)-based rehabilitation. Shaping upper arm-forearm muscle synergies may support individualized motor rehabilitation strategies. Methods Thirty-two chronic stroke patients with no active finger extensions were randomly assigned to experimental or sham groups and underwent daily BMI training followed by physiotherapy during four weeks. BMI sessions included desynchronization of ipsilesional brain activity and a robotic orthosis to move the paretic limb (experimental group, n = 16). In the sham group (n = 16) orthosis movements were random. Motor function was evaluated with electromyography (EMG) of forearm extensors, and upper arm and hand Fugl-Meyer assessment (FMA) scores. Patients performed distinct upper arm (e.g., shoulder flexion) and hand movements (finger extensions). Forearm EMG activity significantly higher during upper arm movements as compared to finger extensions was considered facilitation of forearm EMG activity. Intraclass correlation coefficient (ICC) was used to test inter-session reliability of facilitation of forearm EMG activity. Results Facilitation of forearm EMG activity ICC ranges from 0.52 to 0.83, indicating fair to high reliability before intervention in both limbs. Facilitation of forearm muscles is higher in the paretic as compared to the healthy limb (p<0.001). Upper arm FMA scores predict facilitation of forearm muscles after intervention in both groups (significant correlations ranged from R = 0.752, p = 0.002 to R = 0.779, p = 0.001), but only in the experimental group upper arm FMA scores predict changes in facilitation of forearm muscles after intervention (R = 0.709, p = 0.002; R = 0.827, p<0.001). Conclusions Residual upper arm motor function primes recruitment of paralyzed forearm muscles in chronic stroke patients and predicts changes in their recruitment after BMI training. This study suggests that changes in upper arm-forearm synergies contribute to stroke motor recovery, and provides candidacy guidelines for similar BMI-based clinical practice.en
dc.description.statusPeer reviewed
dc.format.extent2772205
dc.identifier.citationCurado , M R , Garcia-Cossio , E , Broetz , D , Agostini , M , Cho , W , Lima-Brasil , F , Yilmaz , O , Liberati , G , Lepski , G , Birbaumer , N & Ramos-Murguialday , A 2015 , ' Residual Upper Arm Motor Function Primes Innervation of Paretic Forearm Muscles in Chronic Stroke after Brain-Machine Interface (BMI) Training ' , unknown , vol. unknown , no. 10 , e0140161 . https://doi.org/10.1371/journal.pone.0140161
dc.identifier.doi10.1371/journal.pone.0140161
dc.identifier.otherresearchoutputwizard: 11556/222
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=84949266704&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofunknown
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject.keywordsUPPER-EXTREMITY
dc.subject.keywordsUPPER-LIMB
dc.subject.keywordsCORTICAL DAMAGE
dc.subject.keywordsRECOVERY
dc.subject.keywordsPOSTSTROKE
dc.subject.keywordsHEMIPARESIS
dc.subject.keywordsSYNERGIES
dc.subject.keywordsSURVIVORS
dc.subject.keywordsBCI
dc.subject.keywordsEMG
dc.subject.keywordsUPPER-EXTREMITY
dc.subject.keywordsUPPER-LIMB
dc.subject.keywordsCORTICAL DAMAGE
dc.subject.keywordsRECOVERY
dc.subject.keywordsPOSTSTROKE
dc.subject.keywordsHEMIPARESIS
dc.subject.keywordsSYNERGIES
dc.subject.keywordsSURVIVORS
dc.subject.keywordsBCI
dc.subject.keywordsEMG
dc.subject.keywordsMultidisciplinary
dc.subject.keywordsSDG 3 - Good Health and Well-being
dc.subject.keywordsProject ID
dc.subject.keywordsinfo:eu-repo/grantAgreement/EC/FP7/231724/EU/HUman behavioral Modeling for enhancing learning by Optimizing hUman-Robot interaction/HUMOUR
dc.subject.keywordsinfo:eu-repo/grantAgreement/EC/FP7/231724/EU/HUman behavioral Modeling for enhancing learning by Optimizing hUman-Robot interaction/HUMOUR
dc.subject.keywordsFunding Info
dc.subject.keywordsGerman Federal Ministry of Education and Research (BMBF), _x000D_ Deutsche Forschungsgemeinschaft (DFG),_x000D_ European Research Council,_x000D_ European Union Information and Communication Technologies Framework Programme 7 (ICT-FP7),_x000D_ TECNALIA, _x000D_ Baden Wuerttemberg Stiftung,_x000D_ Natural Science Foundation of China,_x000D_ Volkswagen Stiftung,_x000D_ CAPES (Coordination for the Improvement of Higher Level -or Education-Personnel, Brazil),_x000D_ CNPq (Brazilian National Counsel of Technological and Scientific Development),_x000D_ DAAD (Deutscher Akademischer Austauschdienst),_x000D_ Interuniversity Center for the Research in Cognitive Processing of Natural and Artificial Systems (ECoNa),_x000D_ Sapienza University of Rome
dc.subject.keywordsGerman Federal Ministry of Education and Research (BMBF), _x000D_ Deutsche Forschungsgemeinschaft (DFG),_x000D_ European Research Council,_x000D_ European Union Information and Communication Technologies Framework Programme 7 (ICT-FP7),_x000D_ TECNALIA, _x000D_ Baden Wuerttemberg Stiftung,_x000D_ Natural Science Foundation of China,_x000D_ Volkswagen Stiftung,_x000D_ CAPES (Coordination for the Improvement of Higher Level -or Education-Personnel, Brazil),_x000D_ CNPq (Brazilian National Counsel of Technological and Scientific Development),_x000D_ DAAD (Deutscher Akademischer Austauschdienst),_x000D_ Interuniversity Center for the Research in Cognitive Processing of Natural and Artificial Systems (ECoNa),_x000D_ Sapienza University of Rome
dc.titleResidual Upper Arm Motor Function Primes Innervation of Paretic Forearm Muscles in Chronic Stroke after Brain-Machine Interface (BMI) Trainingen
dc.typejournal article
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